Patents by Inventor Sinil Kim
Sinil Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220249535Abstract: The present disclosure relates to compositions comprising Nicotinamide Adenine Dinucleotide (NAD+)-related and precursor compounds, pharmaceutical compositions and kits containing them, and methods for using them.Type: ApplicationFiled: April 2, 2020Publication date: August 11, 2022Inventors: Gary D. ARONSON, Sinil KIM
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Publication number: 20160136181Abstract: A method of treating a subject, for example for a subject with a solid tumor or hematologic malignancy, can include administering a therapeutic treatment cycle to the subject, the cycle including daily microRNA mimic administrations on the first 3-7 consecutive days of the cycle followed by no microRNA administration on the next 7-21 consecutive days of the cycle.Type: ApplicationFiled: April 1, 2015Publication date: May 19, 2016Applicant: Mirna Therapeutics, IncInventor: Sinil Kim
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Patent number: 9205052Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: March 15, 2013Date of Patent: December 8, 2015Assignee: Pacira Pharmaceuticals, Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Patent number: 9192575Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: March 6, 2013Date of Patent: November 24, 2015Assignee: Pacira Pharmaceuticals, Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Patent number: 8834921Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: May 21, 2012Date of Patent: September 16, 2014Assignee: Pacira Pharmaceuticals, Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Publication number: 20120231070Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: PACIRA PHARMACEUTICAL, INC.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Patent number: 8182835Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: April 1, 2005Date of Patent: May 22, 2012Assignee: Pacira Pharmaceuticals, Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Publication number: 20100087306Abstract: Disclosed is a centrifuging device with a detachable cover and a safeguard structure in which the cover of the centrifuging device can be completely separated from the housing; and the safeguard structure can prevent a rotor from becoming separated from a drive shaft during operation due to flange defection and prevent the fractured pieces of the rotor from springing out of the housing when the rotor breaks or cracks. The centrifuging device according to the invention offers ease of cleaning and improved safety. Furthermore, there is no need to worry about the fracture of a coupling portion between the cover and the housing attributable to the repeated opening and closing.Type: ApplicationFiled: January 28, 2009Publication date: April 8, 2010Applicants: iNtRON Biotechnology, Inc., Kinemotion Co., Ltd.Inventors: Seongjun Yoon, Sanghyeon Kang, Jisung Park, Youyoung Choe, Kyungshik Choi, Junghee Kim, Sinil Kim
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Publication number: 20060078606Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: ApplicationFiled: April 1, 2005Publication date: April 13, 2006Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Patent number: 6428529Abstract: A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.Type: GrantFiled: September 16, 1997Date of Patent: August 6, 2002Assignee: SkyePharma Inc.Inventors: Andres Gruber, Sharad B. Murdande, Taehee Kim, Sinil Kim
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Publication number: 20020065506Abstract: A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.Type: ApplicationFiled: September 16, 1997Publication date: May 30, 2002Applicant: SkyePharma, Inc.Inventors: ANDRAS GRUBER, SHARAD B. MURDANDE, TAEHEE KIM, SINIL KIM
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Publication number: 20010029389Abstract: The invention provides a variety of bone marrow-shielding tourniquets and methods for using them to perform bone marrow-shielded chemotherapy with or without general and without the need to remove a patient's bone marrow for protection during the procedure. In the invention method, pressure is applied to at least one body part of the patient that contains myelopoietic bone marrow to temporarily occlude arterial flow to the bone marrow while blood circulation through the remainder of the body is maintained. Then an effective amount of at least one myelosuppresive chemotherapeutic agent is administered to the blood circulation in the remainder of the patient while the arterial flow through the at least one body part is occluded and so that the myelosuppresive effect of the agent is substantially dissipated within the maximum safe period for the occlusion of the arterial flow, or about three hours.Type: ApplicationFiled: March 28, 2001Publication date: October 11, 2001Inventor: Sinil Kim
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Patent number: 6293860Abstract: An improved air filtration method and device by which to more effectively clean the ambient air (19) being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system (10, 15, 16). The notion of a special more conveniently accessible air filtration appliance (21) is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment; yet remains compatible with existing OEM air filtration provision, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.Type: GrantFiled: September 23, 1999Date of Patent: September 25, 2001Inventor: Sinil Kim
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Patent number: 6210423Abstract: The invention provides a variety of bone marrow-shielding tourniquets and methods for using them to perform bone marrow-shielded chemotherapy with or without general and without the need to remove a patient's bone marrow for protection during the procedure. In the invention method, pressure is applied to at least one body part of the patient that contains myelopoietic bone marrow to temporarily occlude arterial flow to the bone marrow while blood circulation through the remainder of the body is maintained. Then an effective amount of at least one myelosuppresive chemotherapeutic agent is administered to the blood circulation in the remainder of the patient while the arterial flow through the at least one body part is occluded and so that the myelosuppresive effect of the agent is substantially dissipated within the maximum safe period for the occlusion of the arterial flow, or about three hours.Type: GrantFiled: January 28, 1999Date of Patent: April 3, 2001Inventor: Sinil Kim
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Patent number: 6132766Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.Type: GrantFiled: March 20, 1998Date of Patent: October 17, 2000Assignee: SkyePharma Inc.Inventors: Mantripragada Bhima Sankaram, Sinil Kim
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Patent number: 6080059Abstract: An air filtration method and device which more effectively clean the ambient air being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system. The notion of more conveniently accessible air filtration appliance is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment, yet remains compatible with existing OEM air filtration provisions, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.Type: GrantFiled: October 20, 1999Date of Patent: June 27, 2000Inventor: Sinil Kim
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Patent number: 6071534Abstract: Disclosed are multivesicular liposomes containing biologically active substances, and having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated release of the biologically active substance. The liposomes are made by a process comprising dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome. A water-in-oil emulsion is made from the two components, the emulsion is immersed into a second aqueous component, and then divided into small solvent spherules which contain even smaller aqueous chambers. The solvents arc finally removed to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.Type: GrantFiled: February 5, 1998Date of Patent: June 6, 2000Assignee: SkyePharma Inc.Inventors: Sinil Kim, Stephen B. Howell
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Patent number: 6045824Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is usefuil for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: September 18, 1998Date of Patent: April 4, 2000Assignee: SkyePharma Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdandi
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Patent number: 6019676Abstract: An air filtration method and device by which to more effectively clean the ambient air (19) being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system (10, 15, 16). The notion of a special more conveniently accessible air filtration appliance (21) is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment; yet remains compatible with existing OEM air filtration provision, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.Type: GrantFiled: July 24, 1997Date of Patent: February 1, 2000Inventor: Sinil Kim
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Patent number: 5993850Abstract: Disclosed are multivesicular liposomes (MVL's) containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a controlled and variable release rate of the biologically active substance. The process involves encapsulating at least one biologically active substance and optionally an osmotic spacer in a first aqueous component encapsulated within the liposomes. The rate of release of the active substance into the surrounding environment in which the liposomes are introduced can be decreased by increasing the osmolarity of the first aqueous component or increased by decreasing the osmolarity.Type: GrantFiled: September 13, 1994Date of Patent: November 30, 1999Assignee: SkyePharma Inc.Inventors: Mantripragada B. Sankaram, Sinil Kim