Patents by Inventor Sin Ki Fung

Sin Ki Fung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compounds for targeted autophagy
    Patent number: 11666661
    Abstract: Provided herein, inter alia, are methods and compounds for targeted autophagy.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: June 6, 2023
    Assignees: The Regents of the University of California, Frontier Medicines Corporation
    Inventors: Daniel K. Nomura, Roberto Zoncu, Carl Ward, Sin Ki Fung, Chris Kumar Varma, Benjamin Fontaine
  • Platinum (II) complexes containing N-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment
    Patent number: 10577387
    Abstract: Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 3, 2020
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Chi Ming Che, Sin Ki Fung, Tian Feng Chen
  • PLATINUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND AND PINCER LIGANDS, SYNTHESIS, AND THEIR APPLICATIONS IN CANCER TREATMENT
    Publication number: 20200048291
    Abstract: Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
    Type: Application
    Filed: August 9, 2018
    Publication date: February 13, 2020
    Inventors: Chi Ming CHE, Sin Ki FUNG, Tian Feng CHEN
  • METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY
    Publication number: 20190290778
    Abstract: Provided herein, inter alia, are methods and compounds for targeted autophagy.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 26, 2019
    Inventors: Daniel K. Nomura, Roberto Zoncu, Carl Ward, Sin Ki Fung, Chris Kumar Varma, Benjamin Fontaine
  • Method of targeting mismatched DNA using d8 square planar metal complexes
    Patent number: 10378046
    Abstract: Disclosed are methods of using d8 square planar metal complexes containing tridentate ?-conjugated ligands and ancillary ligand of N-heterocyclic carbene or di-phosphine ligand to target mismatched DNA. Targeting of mismatched DNA can be revealed by monitoring the differences in emission enhancement of metal complexes toward mismatched DNA and matched DNA; or the gradually heat release from isothermal titration calorimetry (ITC) when complexes bind toward mismatch DNA; or the significant increase in melting temperature of the mismatched DNA after adding complexes.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 13, 2019
    Assignee: The University of Hong Kong
    Inventors: Chi Ming Che, Sin Ki Fung, Taotao Zou
  • METHOD OF TARGETING MISMATCHED DNA USING d8 SQUARE PLANAR METAL COMPLEXES
    Publication number: 20160369354
    Abstract: Disclosed are methods of using d8 square planar metal complexes containing tridentate ?-conjugated ligands and ancillary ligand of N-heterocyclic carbene or di-phosphine ligand to target mismatched DNA. Targeting of mismatched DNA can be revealed by monitoring the differences in emission enhancement of metal complexes toward mismatched DNA and matched DNA; or the gradually heat release from isothermal titration calorimetry (ITC) when complexes bind toward mismatch DNA; or the significant increase in melting temperature of the mismatched DNA after adding complexes.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 22, 2016
    Inventors: Chi Ming Che, Sin Ki Fung, Taotao Zou