Patents by Inventor Sing-Yuen Sit

Sing-Yuen Sit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10493070
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, azadecaline derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: December 3, 2019
    Assignee: ViiV HEALTHCARE UK (NO. 5) LIMITED
    Inventors: Jie Chen, Nicholas A. Meanwell, Alicia Regueiro-Ren, Sing-Yuen Sit, Jacob Swidorski, Yan Chen
  • Publication number: 20190359647
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Inventors: Jie CHEN, Yan Chen, Ira B. Dicker, Richard A. Hartz, Nicholas A. Meanwell, Beata Nowicka-Sans, Alicia Regueiro-Ren, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Lee Venables
  • Publication number: 20190307776
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, aza-substituted triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 10, 2019
    Applicant: ViiV HealthCare UK (No. 5) Limited
    Inventors: Jie CHEN, Yan CHEN, Alicia REGUEIRO-REN, Sing-Yuen SIT, Jacob SWIDORSKI
  • Patent number: 10421774
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: September 24, 2019
    Assignee: ViiV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Jie Chen, Yan Chen, Ira B. Dicker, Richard A. Hartz, Nicholas A. Meanwell, Beata Nowicka-Sans, Alicia Regueiro-Ren, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Lee Venables
  • Publication number: 20190209550
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, azadecaline derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 11, 2019
    Inventors: Jie CHEN, Nicholas A. MEANWELL, Alicia REGUEIRO-REN, Sing-Yuen SIT, Jacob SWIDORSKI, Yan CHEN
  • Publication number: 20190151336
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Inventors: Sing-Yuen SIT, Yan CHEN, Jie CHEN, Jacob SWIDORSKI, Brian Lee VENABLES, Ny SIN, Nicholas A. MEANWELL, Alicia REGUEIRO-REN, Richard A. HARTZ, Li XU, Zheng LIU
  • Patent number: 10245275
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: April 2, 2019
    Assignee: VIIV HEALTHCARE UK (NO. 4) LIMITED
    Inventors: Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob Swidorski, Brian Lee Venables, Ny Sin, Nicholas A. Meanwell, Alicia Regueiro-Ren, Richard A. Hartz, Li Xu, Zheng Liu
  • Publication number: 20190031709
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: February 2, 2017
    Publication date: January 31, 2019
    Inventors: Jie CHEN, Yan CHEN, Ira B. DICKER, Richard A. HARTZ, Nicholas A. MEANWELL, Beata NOWICKA-SANS, Alicia REGUEIRO-REN, Sing-Yuen SIT, Ny SIN, Jacob SWIDORSKI, Brian Lee VENABLES
  • Patent number: 10047118
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: August 14, 2018
    Assignee: ViiV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Jie Chen, Yan Chen, Nicholas A. Meanwell, Alicia Regueiro-Ren, Ny Sin, Sing-Yuen Sit
  • Patent number: 9914747
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 13, 2018
    Assignee: ViiV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Jie Chen, Yan Chen, Nicholas A. Meanwell, Alicia Regueiro-Ren, Sing-Yuen Sit, Jacob Swidorski
  • Publication number: 20170340650
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: August 16, 2017
    Publication date: November 30, 2017
    Inventors: Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob Swidorski, Brian Lee Venables, Ny Sin, Nicholas A. Meanwell, Alicia Regueiro-Ren, Richard A. Hartz, Li Xu, Zheng Liu
  • Publication number: 20170334945
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: November 12, 2015
    Publication date: November 23, 2017
    Inventors: Jie CHEN, Yan CHEN, Nicholas A. MEANWELL, Alicia REGUEIRO-REN, Sing-Yuen SIT, Jacob SWIDORSKI
  • Publication number: 20170305962
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: November 12, 2015
    Publication date: October 26, 2017
    Applicant: ViiV Healthcare UK (No.5) Limited
    Inventors: Jie CHEN, Yan CHEN, Nicholas A. MEANWELL, Alicia REGUEIRO-REN, NY SIN, Sing-Yuen SIT
  • Patent number: 9636375
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: May 2, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alan Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Yan Chen
  • Publication number: 20170056420
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 2, 2017
    Inventors: Sing-Yuen SIT, Yan CHEN, Jie CHEN, Jacob SWIDORSKI, Brian Lee VENABLES, Ny SIN, Nicholas A. MEANWELL, Alicia REGUEIRO-REN, Richard A. HARTZ, Li XU, Zheng LIU
  • Patent number: 9527882
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: December 27, 2016
    Assignee: ViiV Healthcare UK (No.4) Limited
    Inventors: Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob Swidorski, Brian Lee Venables, Ny Sin, Nicholas A. Meanwell, Alicia Regueiro-Ren, Richard A. Hartz, Li Xu, Zheng Liu
  • Publication number: 20160151387
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: Alicia Regueiro-Ren, Zheng Liu, Jacob Swidorski, Ny Sin, Brian Lee Venables, Sing-Yuen Sit, Yan Chen, Jie Chen, Nicholas A. Meanwell
  • Publication number: 20160067302
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Application
    Filed: November 9, 2015
    Publication date: March 10, 2016
    Inventors: Alan Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Yan Chen
  • Patent number: 9249180
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: a compound of Formula I a compound of Formula II a compound of Formula III and a compound of Formula IV The compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: February 2, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacob Swidorski, Yan Chen, Sing-Yuen Sit, Nicholas A. Meanwell, Alicia Regueiro-Ren, Jie Chen, Zheng Liu, Richard A. Hartz, Li Xu
  • Patent number: 9227940
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: January 5, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alan Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Yan Chen