Abstract: Assessing therapeutic efficacy of electrical neurostimulation therapy. A neuromodulation device delivers the electrical neurostimulation therapy. Measurement circuitry captures recordings of neural responses evoked by the electrical neurostimulation therapy. A processor processes the recordings of the neural responses in order to obtain a plurality of measures of neural activation in response to a plurality of stimuli delivered over time, and calculates from the plurality of measures of neural activation at least one statistical measure of neural activation. From the at least one statistical measure the processor produces and outputs an indication of therapeutic efficacy.