Patents by Inventor Sinikka TIISALA

Sinikka TIISALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MMP-8 activation product, its determination and use
    Patent number: 11378579
    Abstract: The present invention relates to a novel MMP-8 activation product such as a MMP-8 middle-part activation product. The invention also relates to detecting such a MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject and to the use thereof for diagnosing diseases which relate to abnormal or elevated levels of activated MMP-8.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: July 5, 2022
    Assignees: Oy Medix Biochemica AB, Dentognostics GmbH
    Inventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Païvi Mäntylä, Ismo Råman, Sinikka Tiisala
  • MMP-8 ACTIVATION PRODUCT, ITS DETERMINATION AND USE
    Publication number: 20200064346
    Abstract: The present invention relates to a novel MMP-8 activation product such as a MMP-8 middle-part activation product. The invention also relates to detecting such a MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject and to the use thereof for diagnosing diseases which relate to abnormal or elevated levels of activated MMP-8.
    Type: Application
    Filed: May 2, 2019
    Publication date: February 27, 2020
    Inventors: Timo SORSA, DIRK-ROLF GIESELMANN, ARMI KORVUO, KURT MAIER, PÄIVI MÄNTYLÄ, ISMO RÅMAN, SINIKKA TIISALA
  • MMP-8 activation product, its determination and use
    Patent number: 10488415
    Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 26, 2019
    Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBH
    Inventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
  • METHOD FOR DETERMINING RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASES
    Publication number: 20190234965
    Abstract: The present invention relates to a novel method for determining risk of cardiovascular diseases comprising detecting of MMP-8 and CRP in a sample, and comparing the detected amounts with respective predetermined values of MMP-8 and CRP, wherein the detection of elevated levels of MMP-8 and CRP is indicative of presence or risk of cardiovascular event or disease. The present invention relates also to the use of detection of MMP-8 and CRP for predicting a risk for getting a cardiovascular event, for monitoring the effect of therapy on cardiovascular event or on cardiovascular disease, or for detecting the presence of a subclinical cardiovascular disease. Also, a method for constructing a risk prediction model for a presence of CVD disease or a risk of CVD events is presented.
    Type: Application
    Filed: September 27, 2017
    Publication date: August 1, 2019
    Inventors: Pirkko PUSSINEN, Timo SORSA, Veikko SALOMAA, Juuso JUHILA, Armi KORVUO, Sinikka TIISALA
  • MMP-8 activation product, its determination and use
    Patent number: 10330681
    Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 25, 2019
    Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBH
    Inventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
  • MMP-8 ACTIVATION PRODUCT, ITS DETERMINATION AND USE
    Publication number: 20170023571
    Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 26, 2017
    Inventors: Timo SORSA, Dirk-Rolf GIESELMANN, Armi KORVUO, Kurt MAIER, Päivi MÄNTYLÄ, Ismo RÅMAN, Sinikka TIISALA