Patents by Inventor Sinil Kim

Sinil Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160136181
    Abstract: A method of treating a subject, for example for a subject with a solid tumor or hematologic malignancy, can include administering a therapeutic treatment cycle to the subject, the cycle including daily microRNA mimic administrations on the first 3-7 consecutive days of the cycle followed by no microRNA administration on the next 7-21 consecutive days of the cycle.
    Type: Application
    Filed: April 1, 2015
    Publication date: May 19, 2016
    Applicant: Mirna Therapeutics, Inc
    Inventor: Sinil Kim
  • Patent number: 9205052
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 8, 2015
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 9192575
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 24, 2015
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 8834921
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 16, 2014
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Publication number: 20120231070
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 13, 2012
    Applicant: PACIRA PHARMACEUTICAL, INC.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 8182835
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: May 22, 2012
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Publication number: 20100087306
    Abstract: Disclosed is a centrifuging device with a detachable cover and a safeguard structure in which the cover of the centrifuging device can be completely separated from the housing; and the safeguard structure can prevent a rotor from becoming separated from a drive shaft during operation due to flange defection and prevent the fractured pieces of the rotor from springing out of the housing when the rotor breaks or cracks. The centrifuging device according to the invention offers ease of cleaning and improved safety. Furthermore, there is no need to worry about the fracture of a coupling portion between the cover and the housing attributable to the repeated opening and closing.
    Type: Application
    Filed: January 28, 2009
    Publication date: April 8, 2010
    Applicants: iNtRON Biotechnology, Inc., Kinemotion Co., Ltd.
    Inventors: Seongjun Yoon, Sanghyeon Kang, Jisung Park, Youyoung Choe, Kyungshik Choi, Junghee Kim, Sinil Kim
  • Publication number: 20060078606
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Application
    Filed: April 1, 2005
    Publication date: April 13, 2006
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 6428529
    Abstract: A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: August 6, 2002
    Assignee: SkyePharma Inc.
    Inventors: Andres Gruber, Sharad B. Murdande, Taehee Kim, Sinil Kim
  • Publication number: 20020065506
    Abstract: A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.
    Type: Application
    Filed: September 16, 1997
    Publication date: May 30, 2002
    Applicant: SkyePharma, Inc.
    Inventors: ANDRAS GRUBER, SHARAD B. MURDANDE, TAEHEE KIM, SINIL KIM
  • Publication number: 20010029389
    Abstract: The invention provides a variety of bone marrow-shielding tourniquets and methods for using them to perform bone marrow-shielded chemotherapy with or without general and without the need to remove a patient's bone marrow for protection during the procedure. In the invention method, pressure is applied to at least one body part of the patient that contains myelopoietic bone marrow to temporarily occlude arterial flow to the bone marrow while blood circulation through the remainder of the body is maintained. Then an effective amount of at least one myelosuppresive chemotherapeutic agent is administered to the blood circulation in the remainder of the patient while the arterial flow through the at least one body part is occluded and so that the myelosuppresive effect of the agent is substantially dissipated within the maximum safe period for the occlusion of the arterial flow, or about three hours.
    Type: Application
    Filed: March 28, 2001
    Publication date: October 11, 2001
    Inventor: Sinil Kim
  • Patent number: 6293860
    Abstract: An improved air filtration method and device by which to more effectively clean the ambient air (19) being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system (10, 15, 16). The notion of a special more conveniently accessible air filtration appliance (21) is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment; yet remains compatible with existing OEM air filtration provision, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: September 25, 2001
    Inventor: Sinil Kim
  • Patent number: 6210423
    Abstract: The invention provides a variety of bone marrow-shielding tourniquets and methods for using them to perform bone marrow-shielded chemotherapy with or without general and without the need to remove a patient's bone marrow for protection during the procedure. In the invention method, pressure is applied to at least one body part of the patient that contains myelopoietic bone marrow to temporarily occlude arterial flow to the bone marrow while blood circulation through the remainder of the body is maintained. Then an effective amount of at least one myelosuppresive chemotherapeutic agent is administered to the blood circulation in the remainder of the patient while the arterial flow through the at least one body part is occluded and so that the myelosuppresive effect of the agent is substantially dissipated within the maximum safe period for the occlusion of the arterial flow, or about three hours.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: April 3, 2001
    Inventor: Sinil Kim
  • Patent number: 6132766
    Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: October 17, 2000
    Assignee: SkyePharma Inc.
    Inventors: Mantripragada Bhima Sankaram, Sinil Kim
  • Patent number: 6080059
    Abstract: An air filtration method and device which more effectively clean the ambient air being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system. The notion of more conveniently accessible air filtration appliance is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment, yet remains compatible with existing OEM air filtration provisions, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: June 27, 2000
    Inventor: Sinil Kim
  • Patent number: 6071534
    Abstract: Disclosed are multivesicular liposomes containing biologically active substances, and having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated release of the biologically active substance. The liposomes are made by a process comprising dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing at least one biologically active substance to be encapsulated, and adding to either or both the organic solvents and the lipid component, a hydrochloride effective to control the release rate of the biologically active substance from the multivesicular liposome. A water-in-oil emulsion is made from the two components, the emulsion is immersed into a second aqueous component, and then divided into small solvent spherules which contain even smaller aqueous chambers. The solvents arc finally removed to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: June 6, 2000
    Assignee: SkyePharma Inc.
    Inventors: Sinil Kim, Stephen B. Howell
  • Patent number: 6045824
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is usefuil for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: April 4, 2000
    Assignee: SkyePharma Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdandi
  • Patent number: 6019676
    Abstract: An air filtration method and device by which to more effectively clean the ambient air (19) being fed into a motor vehicle's passenger compartment, via the existing OEM ventilation and heating/air conditioning system (10, 15, 16). The notion of a special more conveniently accessible air filtration appliance (21) is set forth with generic variants showing adaptability to differently configured OEM air outlets. The new technique contemplates treating the air instantly as it is being discharged into the passenger compartment; yet remains compatible with existing OEM air filtration provision, some of which are provided at the cowl inlet, others are located mid stream within the ducting system.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: February 1, 2000
    Inventor: Sinil Kim
  • Patent number: 5993850
    Abstract: Disclosed are multivesicular liposomes (MVL's) containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a controlled and variable release rate of the biologically active substance. The process involves encapsulating at least one biologically active substance and optionally an osmotic spacer in a first aqueous component encapsulated within the liposomes. The rate of release of the active substance into the surrounding environment in which the liposomes are introduced can be decreased by increasing the osmolarity of the first aqueous component or increased by decreasing the osmolarity.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: November 30, 1999
    Assignee: SkyePharma Inc.
    Inventors: Mantripragada B. Sankaram, Sinil Kim
  • Patent number: 5934270
    Abstract: A heat exchange device is disclosed herein to be used in conjunction with a standard fireplace. The heat exchange device is made from a continuous tube fabricated into loops that surround the burning fuel. The ambient room air, introduced through an opening for air entry into the tube, is blown through the internal lumen of the tube fabricated into loops, the external surfaces of which are in direct contact with burning fuel and flame. The air passing through the internal lumen of the tube fabricated into loops is heated to a high temperature by the burning fuel and flame.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: August 10, 1999
    Inventor: Sinil Kim