Patents by Inventor Sinisa Hrvatin

Sinisa Hrvatin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT ADENO ASSOCIATED VIRUS (RAAV) ENCODING GJB2 AND USES THEREOF
    Publication number: 20230340038
    Abstract: The present disclosure, at least in part, relates to compositions (e.g., isolated nucleic acid and rAAVs) and methods for treating Non-syndromic hearing loss and deafness (DFNB1) by delivering gap junction beta 2 (GJB2) protein to inner ear cells that normally express GJB2 (e.g., fibrocytes and supporting cells of the organ of Corti and nearby regions). The isolated nucleic acid of the present disclosure comprises an expression cassette, wherein the expression cassette comprises a gap junction beta 2 (GJB2) gene regulatory element (GRE) (e.g., GJB2 enhancers, GJB2 promoters, GJB2 5? UTR, and/or GJB2 3? UTR), and a nucleotide sequence encoding a GJB2 protein.
    Type: Application
    Filed: September 14, 2021
    Publication date: October 26, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: David P. Corey, Kevin T. Booth, Cole W. D. Peters, Maryna V. Ivanchenko, Michael E Greenberg, Sinisa Hrvatin, Mark Aurel Nagy, Eric C. Griffith
  • A SCALABLE PLATFORM FOR THE DEVELOPMENT OF CELL-TYPE-SPECIFIC VIRUSES
    Publication number: 20220025398
    Abstract: The technology described herein is directed to adeno-associated vims (AAV) vectors comprising at least one gene regulatory element (GRE) and cells comprising said vectors. In another aspect, described herein are methods of screening for said gene regulatory elements. In another aspect, described herein are nucleic acid compositions comprising a GRE as described herein.
    Type: Application
    Filed: December 5, 2019
    Publication date: January 27, 2022
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Sinisa HRVATIN, Mark Aurel NAGY, Michael E. GREENBERG
  • Compositions and methods for promoting the generation of endocrine cells
    Patent number: 10941384
    Abstract: Disclosed herein are compositions and methods for the generation of insulin positive ? cells, for example by exposing Pdx+ pancreatic progenitor cells to one or more compounds, and compositions and kits comprising isolated populations of insulin positive cells.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 9, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Douglas A. Melton, Sinisa Hrvatin, Shuibing C. Chen
  • MARKERS FOR MATURE BETA-CELLS AND METHODS OF USING THE SAME
    Publication number: 20180179593
    Abstract: Markers for mature ?-cells and methods of using these markers are disclosed.
    Type: Application
    Filed: September 5, 2017
    Publication date: June 28, 2018
    Inventors: Douglas A. Melton, Sinisa Hrvatin
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF ENDOCRINE CELLS
    Publication number: 20160032249
    Abstract: Disclosed herein are compositions and methods for the generation of insulin positive ? cells, for example by exposing Pdx+ pancreatic progenitor cells to one or more compounds, and compositions and kits comprising isolated populations of insulin positive cells.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 4, 2016
    Inventors: Douglas A. Melton, Sinisa Hrvatin, Shuibing C. Chen
  • MARKERS FOR MATURE BETA-CELLS AND METHODS OF USING THE SAME
    Publication number: 20140329704
    Abstract: Markers for mature ?-cells and methods of using these markers are disclosed.
    Type: Application
    Filed: March 28, 2014
    Publication date: November 6, 2014
    Inventors: Douglas A. Melton, Sinisa Hrvatin
  • MARKERS FOR FUNCTIONALLY MATURE BETA-CELLS AND METHODS OF USING THE SAME
    Publication number: 20140287944
    Abstract: Markers for functionally mature ?-cells and methods of using these markers are disclosed.
    Type: Application
    Filed: February 26, 2014
    Publication date: September 25, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Sinisa Hrvatin, Douglas A. Melton, Barak Blum