Patents by Inventor Sinisa Vukelic

Sinisa Vukelic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11957622
    Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: April 16, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • Patent number: 11666481
    Abstract: In various embodiments, a laser is scanned across biological tissue to alter the characteristics of the tissue. To alter the optical characteristics of a cornea, the laser is scanned in an annular pattern over a region having a ratio of the outer diameter of the region to the inner diameter of the region. The laser may also be used to irradiate cartilage in joints to treat osteoarthritis.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: June 6, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Sinisa Vukelic
  • Patent number: 11559433
    Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: January 24, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • Patent number: 11497403
    Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.
    Type: Grant
    Filed: June 10, 2017
    Date of Patent: November 15, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • Publication number: 20210085994
    Abstract: The disclosed subject matter provides systems and methods for modulating cytokine activity in a tissue. The system and methods can be used in a variety of tissues including the cornea. The methods of the disclosed subject matter includes a method of modulating cytokine activity within a cornea without treating keratoconus or altering curvature of the cornea, the method comprising: controlling a light source to apply light energy pulses to corneal tissue; wherein the light energy pulses: (a) are below an optical breakdown threshold for the cornea; (b) ionize water molecules within the treated corneal layer to generate reactive oxygen species; and modulate cytokine activity.
    Type: Application
    Filed: September 24, 2020
    Publication date: March 25, 2021
    Inventor: Sinisa Vukelic
  • Patent number: 10940042
    Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.
    Type: Grant
    Filed: October 23, 2016
    Date of Patent: March 9, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Stephen Trokel
  • Publication number: 20190046102
    Abstract: Fluid monitoring devices and/or systems are provided for monitoring fluid output, including volume and flow rate. A high resolution, low cost electronic fluid monitoring device and system collects fluid such as urine and includes a force sensor that correlates the force of gravity on a fluid collection container with strain and converts it to electrical energy. The force registered on the sensor is correlated with fluid content using a pre-programmed machine learning based algorithm and can be used to identify fluid volume and flow rate. Vertical adjustment and rotational adjustment systems for the device are also described.
    Type: Application
    Filed: September 4, 2018
    Publication date: February 14, 2019
    Inventors: Alexander Kushnir, Sinisa Vukelic
  • Publication number: 20120316446
    Abstract: A system and method for Raman spectral analysis for diagnostic purposes to identify the disease state of biological tissue. The sampled tissue can be any human or animal tissue, including but not limited to prostate, breast, cervical tissue, etc. Raman spectroscopy is used to provide Raman bands which are decomposed and their chemical fingerprints identified after mathematical modeling. The method enables identification of chemical compounds in the tissue being diagnosed. Comparison with reference samples permits inferences concerning the presence or absence of disease, the stage of disease, and/or the response of disease to treatment. The method provides sufficient information about the chemical composition of the tissue to differentiate between normal and abnormal states, and may also reveal the locations of abnormalities. The method may also be used to monitor the treatment of a subject and/or the response of disease to drugs or other treatments.
    Type: Application
    Filed: June 7, 2012
    Publication date: December 13, 2012
    Inventor: Sinisa Vukelic