Abstract: Disclosed herein is a clinical decision support system for predicting a diagnosis of musculoskeletal pathologies, in accordance with some embodiments. Accordingly, the clinical decision support system may include a communication device, a processing device, and a storage device. Further, the communication device may be configured for transmitting questions to a first device and receiving responses corresponding to the questions from the first device. Further, the communication device may be configured for transmitting a prediction to a second device. Further, the processing device may be communicatively coupled with the communication device. Further, the processing device may be configured for analyzing the responses based on a knowledge repository and generating the prediction of a diagnosis of a musculoskeletal pathology using a machine learning model based on the analyzing. Further, the storage device may be communicatively coupled with the processing device.