Abstract: Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a method includes receiving a plurality of additively manufactured objects having excess material thereon. The method can include removing the excess material from the plurality of additively manufactured objects by rotating the plurality of additively manufactured objects. The method can also include adjusting an environmental temperature while rotating the plurality of additively manufactured objects according to a dynamic temperature profile that facilitates removal of the excess material from the plurality of additively manufactured objects. The dynamic temperature profile can include (a) a first temperature configured to decrease a viscosity of the excess material, and (b) a second temperature configured to increase a stiffness of the plurality of additively manufactured objects.

Abstract: Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a method includes receiving a plurality of additively manufactured objects having excess material thereon. The method can include removing the excess material from the plurality of additively manufactured objects by rotating the plurality of additively manufactured objects. The method can also include receiving sensor data indicative of a cleaning status of the plurality of additively manufactured objects. The method can further include adjusting, based on the sensor data, an operational parameter that enhances removal of the excess material from the plurality of additively manufactured objects.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. The plurality of registration elements may comprise one or more attachment supports and one or more retention supports extending from the plurality of registration elements. A dental attachment can be removably coupled to the attachment support. The plurality of registration elements and attachment supports may be located on opposing sides of one or more teeth in order to maintain placement prior to adhering the attachment to the tooth. In some embodiments, each of the plurality of registration elements comprises a tooth registration surface shaped to engage the tooth with a specific position and orientation for accurate positioning of the attachment.

Abstract: The present invention relates to antibodies that bind Acinetobacter baumannii, and their use in the diagnosis of, and the prevention and treatment of, bacterial infection caused by Acinetobacter baumannii. In particular, the present invention relates to monoclonal antibodies that specifically bind at the bacterial wall of Acinetobacter baumannii bacteria, such as on, e.g., living bacteria.

Abstract: Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

Abstract: Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

Abstract: Methods and apparatuses for attaching one or more dental attachments to a dentition. Methods may include placing an attachment placement apparatus on the dentition such that contoured surfaces of the attachment placement apparatus are aligned with correspondingly shaped tooth surfaces of the dentition. A body of the attachment placement apparatus may position the dental attachment(s) against specified location(s) on one or more teeth of the dentition. The dental attachment(s) may be coupled to supports that extend from the body. The supports may include breakable regions configured to be broken to facilitate removal of a corresponding dental attachment from the body. The supports may position the dental attachment(s) within corresponding aperture(s) of the attachment placement apparatus. The dental attachment(s) may be secured at the specified location(s) on the teeth.

Abstract: The present application relates to components, such as dental apparatuses, having geometrical features to facilitate post-fabrication cleaning, including methods of fabricating the same. In one embodiment, a dental apparatus comprises one or more concave surfaces that are configured to engage a dental arch of a patient, and at least one aperture located at and formed through the one or more concave surfaces.

Abstract: Dental attachment placement apparatuses and methods for positioning and/or replacing dental attachments when bonding the dental attachments on a patient's teeth. The apparatuses may include a body configured for placement on the patient's dental arch. The body may include receptacles for receiving tooth registration anchors. Each tooth registration anchor may include a first end that is detachably connected to a corresponding dental attachment, and a second end that is shaped and sized to fit into a corresponding receptacle of the body to secure the tooth registration anchor to the body. The second end may be removable from the corresponding receptacle to detach the tooth registration anchor from the body.

Abstract: Systems for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon, an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects, and an energy source configured to apply energy to the plurality of additively manufactured objects to selectively alter a material property of a portion of each of the plurality of additively manufactured objects.

Abstract: Dental attachment placement templates and dental appliance systems. The dental attachment placement templates may include a body configured to position a dental attachment over an attachment site on a surface of a tooth. The body may include an aperture, supports that extend from the body within the aperture, a connection member that connects the dental attachment to the supports, and a contoured surface shaped to register with one or more teeth. The connection member may be integrally formed with the dental attachment to provide a unitary structure. The connection member may be joined to the dental attachment at a breakable single point of connection and being further joined to the supports such that when the single point of connection is broken, the dental attachment is detached from the supports.

Abstract: The present invention relates to a method of diagnosing depression in a subject. Specifically, the present invention relates to diagnosing depression in a subject by providing a sample of the microbiome from the subject; determining the quantitative level or presence of one or more bacterial species in the sample; and diagnosing depression based on the quantitative level or presence of the one or more bacterial species in the sample.

Abstract: Aligner attachment placement devices for placing one or more aligner attachments on teeth. The placement devices can include registration anchors, retention supports, an aligner attachment, and an attachment frame that at least partially surrounds a perimeter of the aligner attachment. The registration anchors can have occlusal contact surfaces that are shaped to register with occlusal surfaces of one or more teeth. The retention supports can have lingual contact surfaces that are shaped to register with lingual surfaces of one or more teeth. The aligner attachments can be shaped to interact with one or more aligners to impart forces on one or more of the teeth. The placement device can include multiple aligner attachments. The attachment frame can include one or more struts that frangibly connect the aligner attachment(s) to the attachment frame.

Abstract: Dental attachment placement apparatuses with one or more replacement attachment systems for providing one or more replacement dental attachments. The replacement attachment systems may include a body that is configured to orient and align the apparatus with respect to the teeth. The apparatus may include one or more primary dental attachments coupled to the body, where the body is configured to position the primary dental attachments adjacent to the teeth for bonding. The replacement system can be configured to replace the primary dental attachments and align replacement dental attachments with respect to the teeth.

Abstract: The present application relates to components, such as dental apparatuses, having geometrical features to facilitate post-fabrication cleaning, including methods of fabricating the same. In one embodiment, a dental apparatus, such as a retainer, an aligner, or a dental attachment placement appliance, comprises one or more concave surfaces for which one or more apertures is formed therethrough at or near a maximum depth of a given concave surface.

Abstract: Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a method includes receiving a plurality of additively manufactured objects on a rotor, the plurality of additively manufactured objects having excess material thereon. The method can include removing the excess material from the plurality of additively manufactured objects by rotating the plurality of additively manufactured objects via the rotor. The method can further include applying energy to the plurality of additively manufactured objects to cure a portion of each additively manufactured object while the plurality of additively manufactured objects are on the rotor.

Abstract: Aligner attachment placement devices including a frame configured to extend over at least a portion of a dental arch, an attachment support extending from a first side of the frame, an aligner attachment frangibly connected to the attachment support, a first and second registration anchor, and a retention support extending from a second side of the frame. In some cases, a gap portion of the frame between the first and second registration anchors may be configured to suspend over one or more teeth of the dental arch. The retention support may be separate from and located between the first and second registration anchors. The retention support may include an extension arm and a tooth contact portion, where at least part of the extension arm has a smaller width than the tooth contact portion.

Abstract: A chimeric mouse-human antibody for treatment of amyloid deposition diseases, pharmaceutical compositions comprising the antibody, methods and materials for producing the antibody, and methods for treating an amyloid deposition disease using the antibody and the pharmaceutical composition.

Abstract: Dental retainer devices are provided. The dental retainer devices can be customized based on patient specific dental anatomy and dental treatment plans. Methods of making the dental retainer devices are also provided. The methods can included additive manufacturing. Methods are also provided for customization of a dental retainer device based on the patient specific anatomy. The methods for customization can include providing a dentist with different options for anterior teeth coverage, posterior teeth coverage, and palatal configurations for the dental retainer devices.

Abstract: Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a method includes receiving a plurality of additively manufactured objects on a rotor, the plurality of additively manufactured objects having excess material thereon. The method can include removing the excess material from the plurality of additively manufactured objects by rotating the plurality of additively manufactured objects via the rotor. The method can further include applying energy to the plurality of additively manufactured objects to cure a portion of each additively manufactured object while the plurality of additively manufactured objects are on the rotor.