Patents by Inventor Siquan Sun

Siquan Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PAR2 MODULATION AND METHODS THEREOF
    Publication number: 20220125898
    Abstract: Provided herein are methods of identifying an agent that activates a protease-activated receptor 2 (PAR2)intracellularly. Also provided are isolated mutant PAR2 polypeptides, isolated polynucleotides encoding the mutant PAR2 polypeptides, vectors comprising the isolated polynucleotides, and host cells comprising the vectors.
    Type: Application
    Filed: April 30, 2020
    Publication date: April 28, 2022
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: Changlu LIU, Siquan SUN, Grace STEEMERS-LEE, Belinda LIU
  • Method for treating allergies using substituted pyrazoles
    Patent number: 7332494
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: February 19, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Substituted pyrazoles and methods of treatment with substituted pyrazoles
    Publication number: 20070117785
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
    Type: Application
    Filed: October 4, 2006
    Publication date: May 24, 2007
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Joanne Quan, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei, Ann Welton
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20070105841
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 10, 2007
    Inventors: J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Yin Gu, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei
  • Method of monitoring the effect of Cathepsin S inhibitors
    Patent number: 7026132
    Abstract: The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed subjects.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: April 11, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robin Thurmond, Siquan Sun, Lars Karlsson
  • Toll-like receptor 9 effector agents and uses thereof
    Publication number: 20050244410
    Abstract: Cell surface TLR9 and TLR9 ligand binding agents are disclosed. The binding agents include antibodies and other proteins. The binding agents are useful as therapeutics, diagnostics or research reagents.
    Type: Application
    Filed: April 29, 2004
    Publication date: November 3, 2005
    Inventors: Ashlyn Bassiri, Anuk Das, Susan Dillon, Karen Duffy, Jonathan Seideman, M. Mbow, Lars Karlsson, Siquan Sun, Jian Zhu, Mark Cunningham
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20050101587
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: September 5, 2001
    Publication date: May 12, 2005
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Yin Gu, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei
  • Heterocyclic compounds
    Publication number: 20050085487
    Abstract: Heterocyclic compounds and methods of making them and using them.
    Type: Application
    Filed: October 8, 2004
    Publication date: April 21, 2005
    Inventors: Nicholas Carruthers, Wenying Chai, Curt Dvorak, James Edwards, Cheryl Grice, Jill Jablonowski, Lars Karlsson, Haripada Khatuya, Jennifer Kreisberg, Annette Kwok, Timothy Lovenberg, Kiev Ly, Barbara Pio, Chandravadan Shah, Siquan Sun, Robin Thurmond, Jianmei Wei, Wei Xiao
  • Use of histamine H4 receptor antagonist for the treatment of inflammatory responses
    Publication number: 20040105856
    Abstract: The present invention relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of inflammatory responses, inflammation, or diseases and/or conditions that are modulated, affected or caused by inflammation or inflammatory responses. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of polymorphonuclear leukocyte responses, such as migration to a particular site, or diseases and/or conditions that are modulated, affected or caused by polymorphonuclear leukocytes. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of mast cell responses, such as de-granulation, or diseases and/or conditions that are modulated, affected or caused by mast cells.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 3, 2004
    Inventors: Robin Thurmond, Siquan Sun, Lars Karlsson
  • Heterocyclic compounds
    Publication number: 20030207893
    Abstract: Heterocyclic compounds and methods of making them and using them.
    Type: Application
    Filed: March 8, 2002
    Publication date: November 6, 2003
    Inventors: Nicholas I. Carruthers, Wenying Chai, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Lars Karlsson, Haripada Khatuya, Jennifer D. Kreisberg, Annette K. Kwok, Timothy W. Lovenberg, Kiev S. Ly, Barbara Pio, Chandravadan R. Shah, Siquan Sun, Robin L. Thurmond, Jianmei Wei, Wei Xiao
  • Use of histamine H4 receptor antagonist for the treatment of inflammatory responses
    Publication number: 20030133931
    Abstract: The present invention relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of inflammatory responses, inflammation, or diseases and/or conditions that are modulated, affected or caused by inflammation or inflammatory responses. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of polymorphonuclear leukocyte responses, such as migration to a particular site, or diseases and/or conditions that are modulated, affected or caused by polymorphonuclear leukocytes. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of mast cell responses, such as de-granulation, or diseases and/or conditions that are modulated, affected or caused by mast cells.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 17, 2003
    Inventors: Robin Thurmond, Siquan Sun, Lars Karlsson
  • Method for treating allergies using substituted pyrazoles
    Patent number: 6583155
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: June 24, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Christopher R. Butler, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Clark A. Sehon, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Patent number: 6579896
    Abstract: A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: June 17, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Hui Cai, James P. Edwards, Yin Gu, Lars Karlsson, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20030073672
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: September 5, 2001
    Publication date: April 17, 2003
    Inventors: J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Kevin L. Tays, Robin L. Thumond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20030069240
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: February 13, 2002
    Publication date: April 10, 2003
    Inventors: J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20020147189
    Abstract: A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.
    Type: Application
    Filed: September 5, 2001
    Publication date: October 10, 2002
    Inventors: Hui Cai, James P. Edwards, Yin Gu, Lars Karlsson, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20020115656
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: February 13, 2002
    Publication date: August 22, 2002
    Inventors: Christopher R. Butler, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Clark A. Sehon, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20020055497
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: September 5, 2001
    Publication date: May 9, 2002
    Inventors: Christopher R. Butler, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Clark A. Sehon, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Method for treating allergies
    Patent number: 6369032
    Abstract: Use of cathepsin S inhibitors for the treatment of an allergic condition, in particular an atopic allergic condition, more specifically for the treatment of hay fever, asthma, atopic dermatitis or a food allergy.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: April 9, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Yin Gu, Lars Karlsson, Siquan Sun, Robin L. Thurmond
  • Method for treating allergies
    Publication number: 20020035108
    Abstract: Use of cathepsin S inhibitors for the treatment of an allergic condition, in particular an atopic allergic condition, more specifically for the treatment of hay fever, asthma, atopic dermatitis or a food allergy.
    Type: Application
    Filed: September 5, 2001
    Publication date: March 21, 2002
    Inventors: Yin Gu, Lars Karlsson, Siquan Sun, Robin L. Thurmond