Patents by Inventor Siqun Xu

Siqun Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic inhibition by double-stranded RNA
    Patent number: 10358653
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 23, 2019
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20160208280
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 21, 2016
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig c. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 9102939
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 11, 2015
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20140350083
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 8580754
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 12, 2013
    Assignees: Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • GENETIC INHIBITION BY DOUBLE-STRANDED RNA
    Publication number: 20130230492
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: October 8, 2012
    Publication date: September 5, 2013
    Applicants: THE UNIVERSITY OF MASSACHUSETTS, CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20130029425
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition of double-stranded RNA
    Patent number: 8283329
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 9, 2012
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Nematode phosphoethanolamine N-methyltransferase-like sequences
    Patent number: 8198060
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: June 12, 2012
    Assignee: Divergence, Inc.
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu
  • Nematode fatty acid desaturase-like sequences
    Patent number: 7993894
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: August 9, 2011
    Assignee: Divergence, Inc.
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. DaVila-Aponte, Siqun Xu, Anita M. Frevert
  • Nematode phosphoethanolamine N-methyltransferase-like sequences
    Patent number: 7867749
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: January 11, 2011
    Assignee: Divergence, Inc.
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert-Thompson, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu
  • Nematode Fatty Acid Desaturase-Like Sequences
    Publication number: 20100248357
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Application
    Filed: January 15, 2009
    Publication date: September 30, 2010
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. DaVila-Aponte, Siqun Xu, Anita M. Frevert
  • Nematode fatty acid desaturase-like sequences
    Patent number: 7666642
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: February 23, 2010
    Assignee: Divergence, Inc.
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Genetic inhibition by double-stranded RNA
    Patent number: 7622633
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: November 24, 2009
    Assignee: Carnegie Institution of Washington
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Nematode Fatty Acid Desaturase-Like Sequences
    Publication number: 20090203127
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Application
    Filed: January 15, 2009
    Publication date: August 13, 2009
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Genetic inhibition by double-stranded RNA
    Patent number: 7560438
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: July 14, 2009
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 7538095
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: May 26, 2009
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Nematode Phosphoethanolamine N-Methyltransferase-Like Sequences
    Publication number: 20090123986
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Application
    Filed: October 28, 2008
    Publication date: May 14, 2009
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu
  • Nematode fatty acid desaturase-like sequences
    Patent number: 7479382
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: January 20, 2009
    Assignee: Divergence, Inc.
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Nematode phosphoethanolamine N-methyltransferase-like sequences
    Patent number: 7442533
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: October 28, 2008
    Assignee: Divergence, Inc.
    Inventors: Deryck J. Williams, Merry B. McLaird, Michelle Coutu Hresko, Anita M. Frevert, Ronald E. Worthington, Andrew P. Kloek, Jennifer A. Davila-Aponte, John D. Bradley, Siqun Xu