Patents by Inventor Sirkka Kyostio-Moore

Sirkka Kyostio-Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF IMPROVED HUMAN PAH FOR TREATMENT OF SEVERE PKU BY LIVER-DIRECTED GENE REPLACEMENT THERAPY
    Publication number: 20210348135
    Abstract: Provided herein are variant phenylalanine hydroxylase (PAH) polypeptides which are more stable and have greater activity than wild-type human PAH. Also provided are methods to treat phenylketonuria (PKU) and/or to reduce levels of phenylalanine in an individual in need thereof. Further provided herein are expression cassettes, vectors (e.g., rAAV vectors), viral particles, pharmaceutical compositions and kits for expressing the variant PAH polypeptide in an individual in need thereof.
    Type: Application
    Filed: October 11, 2019
    Publication date: November 11, 2021
    Inventors: Sirkka KYOSTIO-MOORE, Partha MANAVALAN
  • Production of oversized adeno-associated vectors
    Patent number: 10815497
    Abstract: Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb). In some aspects, the invention provides AAV particles and AAV vectors comprising oversized rAAV genomes. Producer cell lines to produce AAV particles comprising oversized genomes are also provided.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: October 27, 2020
    Assignee: Genzyme Corporation
    Inventors: Sirkka Kyostio-Moore, David Souza, Karen Vincent
  • PRODUCTION OF OVERSIZED ADENO-ASSOCIATED VECTORS
    Publication number: 20190048362
    Abstract: Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb). In some aspects, the invention provides AAV particles and AAV vectors comprising oversized rAAV genomes. Producer cell lines to produce AAV particles comprising oversized genomes are also provided.
    Type: Application
    Filed: April 7, 2016
    Publication date: February 14, 2019
    Inventors: Sirkka KYOSTIO-MOORE, David SOUZA, Karen VINCENT
  • FUSION PROTEINS CONTAINING TWO TGF-BETA BINDING DOMAINS OF TGF-BETA TYPE II RECEPTOR
    Publication number: 20100204104
    Abstract: The disclosure provides fusion proteins that contain two TGF-? binding domains of TGF-? type II receptor joined to each other by a linker. For example, the C terminus of the first TGF-? binding domain is joined by a short peptide linker (e.g., a 9-glycine linker) to the N terminus of the second TGF-? binding domain. Despite the proximity of the C terminus of the first domain to N terminus of the second domain, such a fusion protein effectively neutralizes TGF-?, in some cases, similarly to anti-TGF-? antibodies.
    Type: Application
    Filed: December 24, 2008
    Publication date: August 12, 2010
    Inventors: Huawei Qiu, Steven R. Ledbetter, Sirkka Kyostio-Moore