Publication number: 20040014726
Abstract: The present invention is directed to a method for the preparation of a pharmaceutical composition having osteoclast formation inhibiting or suppressing activity, characterized in that, as the active agent, a compound of the formula (I) is used, in which formula Q1 is hydrogen, hydroxyl, halogen, amino —NH2, or —OR′, wherein R′ is C1-C4-alkyl or acyl, Q2 is straight or branched alkyl, hydroxyalkyl or aminoalkyl, or a corresponding unsaturated group optionally substituted at the hydroxy or amino group, or a unsubstituted or substituted, saturated or unsaturated cycloalkyl, which can be bound to the methylene carbon over a straight or branched alkylene group, or is the group (a) wherein Y is a saturated or unsaturated heterocyclic group, or a carbocyclic aromatic group, X is a bond, O, S or NR3, wherein R3 is hydrogen or a protecting group, especially lower alkyl, acyl, aryl or arylalkyl, and n is an integer 0 to 6, R1 and R2 are independently hydrogen or C1-C4-alkyl, or it is halogen, an
Type:
Application
Filed:
April 25, 2003
Publication date:
January 22, 2004
Inventors:
Thua Osterman, Ritva Hannuniemi, Teuvo Hentunen, Sirpa Liukko-Sipi, Hannu Nikander, Katri Selander, Raija Sellman, Kalervo Vaananen
