Patents by Inventor Sisi FU

Sisi FU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and selection of cells for producing bispecific antibodies
    Patent number: 10793619
    Abstract: Provided are compositions and methods for preparing a cell suitable for producing a bispecific antibody. A plurality of eukaryotic cells are incubated with an agent under conditions to allow the cells to arrest at G1/S phase. The agent is then removed from the cells and the cells are transfected with a first vector comprising a sequence encoding a first monovalent antigen-binding unit having specificity to a first antigen and a second vector comprising a sequence encoding a second monovalent antigen-binding unit having specificity to a second antigen. A cell is identified from the plurality of cells that expresses both the first and the second antigen-binding units.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: October 6, 2020
    Assignee: Wuhan YZY Biopharma Co., Ltd.
    Inventors: Pengfei Zhou, Jing Zhang, Rui Wang, Xiang Zhou, Xiaoyan Liu, Lingli Hu, Sisi Fu, Hui Zhong
  • PREPARATION AND SELECTION OF CELLS FOR PRODUCING BISPECIFIC ANTIBODIES
    Publication number: 20170088604
    Abstract: Provided are compositions and methods for preparing a cell suitable for producing a bispecific antibody. A plurality of eukaryotic cells are incubated with an agent under conditions to allow the cells to arrest at G1/S phase. The agent is then removed from the cells and the cells are transfected with a first vector comprising a sequence encoding a first monovalent antigen-binding unit having specificity to a first antigen and a second vector comprising a sequence encoding a second monovalent antigen-binding unit having specificity to a second antigen. A cell is identified from the plurality of cells that expresses both the first and the second antigen-binding units.
    Type: Application
    Filed: June 5, 2014
    Publication date: March 30, 2017
    Inventors: Pengfei ZHOU, Jing ZHANG, Rui WANG, Xiang ZHOU, Xiaoyan LIU, Lingli HU, Sisi FU, Hui ZHONG