Patents by Inventor Sisi Ni

Sisi Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF GPP AND CBGA IN A METHYLOTROPHIC YEAST STRAIN
    Publication number: 20230043569
    Abstract: This invention is an improved method of robust and scalable production of precursors of active cannabinoids, including geranyl pyrophosphate (GPP) and/or cannabigerolic acid (CBGA), in a methylotrophic yeast host cell. The improved methods incorporate a polypeptide encoding an Erg20 variant (F98W/N128W) into a methylotrophic yeast host cell, for example Pichia pastoris (Komagataella phaffii), that biases the natural production of FPP and GPP towards GPP, a precursor to the intermediate CBGA, crucial to the synthesis of active cannabinoids.
    Type: Application
    Filed: February 28, 2022
    Publication date: February 9, 2023
    Applicant: Exponential Genomics Canada Inc.
    Inventors: David F. Preiner, Casey W. Solomon, Sisi Ni, John W. Harrold, JR.