Abstract: Disclosed are a decoquinate liposome, a preparation method therefor and a use thereof. The preparation raw materials for the decoquinate liposome comprise the following components in parts by weight: 1 part of decoquinate and 2-20 parts of lecithin. The liposome is stable, shows favorable malaria resistance effects in-vivo and in-vitro with respect to animal bodies, can be used for quickly relieving the conditions of malaria, particularly subtertian malaria, and is safe. The preparation method is simple and feasible, and has the potential for mass production.