Patents by Inventor Siu Chung Chim
Siu Chung Chim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11597977Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: GrantFiled: March 2, 2020Date of Patent: March 7, 2023Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
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Patent number: 10947593Abstract: The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth.Type: GrantFiled: August 21, 2019Date of Patent: March 16, 2021Assignee: The Chinese University of Hong KongInventors: Stephen Siu-Chung Chim, Chee Yin Cheung, Wan Chee Cheung, Tak Yeung Leung, Wing Shan Lee
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Publication number: 20200270694Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: ApplicationFiled: March 2, 2020Publication date: August 27, 2020Inventors: YUK MING DENNIS LO, Wai Kwun Rossa Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
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Patent number: 10731217Abstract: Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.Type: GrantFiled: May 21, 2018Date of Patent: August 4, 2020Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Nancy Bo Yin Tsui
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Patent number: 10683557Abstract: It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. In addition, it provides a method for determining the risk of having advanced cervical dilation and/or premature cervical shortening based on differentially abundant bacterial taxa.Type: GrantFiled: June 23, 2015Date of Patent: June 16, 2020Assignee: The Chinese University of Hong KongInventors: Stephen Siu-Chung Chim, Chee-Yin Cheung, Wan-Chee Cheung, Meng Meng, Tak-Yeung Leung, Keun-Young Lee
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Patent number: 10604808Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: GrantFiled: December 14, 2017Date of Patent: March 31, 2020Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
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Publication number: 20190376140Abstract: The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth.Type: ApplicationFiled: August 21, 2019Publication date: December 12, 2019Inventors: Stephen Siu-Chung CHIM, Chee Yin Cheung, Cheung Cheung, Tak Yeung Leung, Wing Shan Lee
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Patent number: 10428383Abstract: The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth.Type: GrantFiled: June 20, 2014Date of Patent: October 1, 2019Assignee: The Chinese University of Hong KongInventors: Stephen Siu-Chung Chim, Chee Yin Cheung, Wan Chee Cheung, Tak Yeung Eung, Wing Shan Lee
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Publication number: 20180327846Abstract: Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.Type: ApplicationFiled: May 21, 2018Publication date: November 15, 2018Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Nancy Bo Yin Tsui
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Patent number: 10006087Abstract: Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.Type: GrantFiled: April 13, 2015Date of Patent: June 26, 2018Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Nancy Bo Yin Tsui
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Publication number: 20180155791Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: ApplicationFiled: December 14, 2017Publication date: June 7, 2018Inventors: Yuk Ming Dennis LO, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
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Patent number: 9862999Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: GrantFiled: February 1, 2016Date of Patent: January 9, 2018Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu-Chung Chim, Yu-Kwan Tong, Chunming Ding
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Publication number: 20170114396Abstract: It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. In addition, it provides a method for determining the risk of having advanced cervical dilation and/or premature cervical shortening based on differentially abundant bacterial taxa.Type: ApplicationFiled: June 23, 2015Publication date: April 27, 2017Applicant: THE CHINESE UNIVERSITY OF HONG KONGInventors: Stephen Siu-Chung CHIM, Chee-Yin CHEUNG, Wan-Chee CHEUNG, Meng MENG, Tak-Yeung LEUNG, Keun-Young LEE
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Publication number: 20160258018Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: ApplicationFiled: February 1, 2016Publication date: September 8, 2016Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu-Chung Chim, Yu-Kwan Tong, Chunming Ding
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Publication number: 20150284800Abstract: Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.Type: ApplicationFiled: April 13, 2015Publication date: October 8, 2015Inventors: YUK-MING DENNIS LO, ROSSA WAI KWUN CHIU, STEPHEN SIU CHUNG CHIM, NANCY BO YIN TSUI
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Patent number: 8927216Abstract: This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.Type: GrantFiled: September 14, 2012Date of Patent: January 6, 2015Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Chunming Ding, Kwan Chee Chan, Hing Nam Ivy Wong, Ka Chun Ryan Yuen
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Publication number: 20130084566Abstract: This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.Type: ApplicationFiled: September 14, 2012Publication date: April 4, 2013Applicant: The Chinese University of Hong KongInventors: YUK MING DENNIS LO, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Chunming Ding, Kwan Chee Chan, Hing Nam Ivy Wong, Ka Chun Ryan Yuen
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Patent number: 8288100Abstract: This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.Type: GrantFiled: June 1, 2010Date of Patent: October 16, 2012Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Chunming Ding, Kwan Chee Chan, Hing Nam Ivy Wong, Ka Chun Ryan Yuen
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Publication number: 20120003650Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: ApplicationFiled: August 22, 2011Publication date: January 5, 2012Applicant: The Chinese University of Hong KongInventors: Yuk Ming Dennis LO, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
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Patent number: 8026067Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.Type: GrantFiled: March 15, 2010Date of Patent: September 27, 2011Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-kwan Tong, Chunming Ding