Patents by Inventor Siu Kwan Sze

Siu Kwan Sze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Exosomal Biomarkers for Cardiovasular Events
    Publication number: 20140024046
    Abstract: The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in an exosome sample from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. Alternatively, the exosomes are present in a body fluid, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2, Serpin G1 or any combination of two or more of these proteins. The invention further relates to a method of diagnosing the occurrence of acute coronary syndrome in a subject, comprising determining the presence of a biomarker that is indicative of the occurrence of acute coronary syndrome in an exosome sample from the subject.
    Type: Application
    Filed: February 17, 2012
    Publication date: January 23, 2014
    Applicant: CAVADIS B.V.
    Inventors: Dominique De Kleijn, Gerard Pasterkamp, Leonardus Timmers, Siu Kwan Sze
  • Determination of Exosomel Biomarkers for Predicting Cardiovascular Events
    Publication number: 20120309041
    Abstract: The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in exosomes from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2 or any combination of two or more of these proteins.
    Type: Application
    Filed: January 7, 2011
    Publication date: December 6, 2012
    Inventors: Leonardus Timmers, Siu Kwan Sze, Dominicus Paschalis Victor De Kleijn
  • Composite MALDI matrix material and methods of using it and kits thereof in MALDI
    Publication number: 20060261267
    Abstract: The present invention relates to a composite matrix material for Matrix-assisted Laser Desorption/Ionisation (MALDI), a process for preparing the same, and a method of its use in MALDI. The invention also relates to a kit for carrying out MALDI. The matrix material comprises at least one MALDI matrix forming compound and a polymer. The polymer serves as supporting material for the at least one MALDI matrix forming compound to which it is covalently linked.
    Type: Application
    Filed: May 20, 2005
    Publication date: November 23, 2006
    Inventors: Siu Kwan Sze, Lin Hua