Patents by Inventor Siu-Tung Yau
Siu-Tung Yau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210032586Abstract: Bio-reactive systems for voltage controlled metabolism are described, that include electrochemical-electrostatic systems having a conventional three electrode cell modified with at least one additional gating electrode. The rate of a metabolic process occurring in at least one organism disposed on a working electrode is controllable by applying a gating voltage VG to the at least one gating electrode. A method for voltage controlled metabolism in a bio-reactive electrostatic cell that includes applying a gating voltage VG to at least one gating electrode is also described. The rate of a metabolic process may he controlled by altering at least one of the magnitude and polarity of the applied gating voltage VG. The method for voltage controlled metabolism may further be used to treat cancer and/or increase the rate of ethanol production by fermentation.Type: ApplicationFiled: September 18, 2020Publication date: February 4, 2021Inventor: Siu-Tung YAU
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Patent number: 10851338Abstract: Bio-reactive systems for voltage controlled metabolism are described, that include electrochemical-electrostatic systems having a conventional three electrode cell modified with at least one additional gating electrode. The rate of a metabolic process occurring in at least one organism disposed on a working electrode is controllable by applying a gating voltage VG to the at least one gating electrode. A method for voltage controlled metabolism in a bio-reactive electrostatic cell that includes applying a gating voltage VG to at least one gating electrode is also described. The rate of a metabolic process may be controlled by altering at least one of the magnitude and polarity of the applied gating voltage VG. The method for voltage controlled metabolism may further be used to treat cancer and/or increase the rate of ethanol production by fermentation.Type: GrantFiled: July 26, 2018Date of Patent: December 1, 2020Inventor: Siu-Tung Yau
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Publication number: 20190024035Abstract: Bio-reactive systems for voltage controlled metabolism are described, that include electrochemical-electrostatic systems having a conventional three electrode cell modified with at least one additional gating electrode. The rate of a metabolic process occurring in at least one organism disposed on a working electrode is controllable by applying a gating voltage VG to the at least one gating electrode. A method for voltage controlled metabolism in a bio-reactive electrostatic cell that includes applying a gating voltage VG to at least one gating electrode is also described. The rate of a metabolic process may be controlled by altering at least one of the magnitude and polarity of the applied gating voltage VG. The method for voltage controlled metabolism may further be used to treat cancer and/or increase the rate of ethanol production by fermentation.Type: ApplicationFiled: July 26, 2018Publication date: January 24, 2019Inventor: Siu-Tung YAU
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Patent number: 9605295Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.Type: GrantFiled: June 26, 2012Date of Patent: March 28, 2017Assignee: CLEVELAND STATE UNIVERSITYInventor: Siu-Tung Yau
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Publication number: 20160333301Abstract: Bio-reactive systems for voltage controlled metabolism are described, that include electrochemical-electrostatic systems having a conventional three electrode cell modified with at least one additional gating electrode. The rate of a metabolic process occurring in at least one organism disposed on a working electrode is controllable by applying a gating voltage VG to the at least one gating electrode. A method for voltage controlled metabolism in a bio-reactive electrostatic cell that includes applying a gating voltage VG to at least one gating electrode is also described. The rate of a metabolic process may be controlled by altering at least one of the magnitude and polarity of the applied gating voltage VG. The method for voltage controlled metabolism may further be used to treat cancer and/or increase the rate of ethanol production by fermentation.Type: ApplicationFiled: January 6, 2015Publication date: November 17, 2016Inventor: Siu-Tung Yau
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Patent number: 8585879Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.Type: GrantFiled: November 7, 2008Date of Patent: November 19, 2013Assignee: Cleveland State UniversityInventor: Siu-Tung Yau
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Publication number: 20120267255Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.Type: ApplicationFiled: June 26, 2012Publication date: October 25, 2012Inventor: Siu-Tung Yau
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Patent number: 8029944Abstract: The invention provides the use of silicon particles as redox catalyst, an electrochemical device and method thereof. As electrocatalyst, the silicon particles catalyze a redox reaction such as oxidization of the redox reactant such as renewable fuels e.g. methanol, ethanol and glucose. The device such as a fuel cell comprises a redox reactant and a catalytic composition comprising silicon nanoparticles. The silicon particles catalyze the redox reaction on an electrode such as anode in the device. In preferred embodiments, the electrocatalysis is dramatically improved under low illuminance such as in darkness. The invention can be widely used in applications related to for example a fuel cell, a sensor, an electrochemical reactor, and a memory.Type: GrantFiled: May 21, 2008Date of Patent: October 4, 2011Assignee: Cleveland State UniversityInventors: Siu-Tung Yau, Munir H. Nayfeh, Gang Wang
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Publication number: 20110123907Abstract: The invention provides an electrode and an electrochemical device including the electrode. The electrode comprises a spatial confining structure such as grooves and an active compound such as glucose oxidase (GOx). The grooves spatially confines GOx, and stabilizes its enzymatic activity. Also provided is a method of stabilizing the activity of an active compound such as GOx. The invention can be widely used in development of an energy-generation device such as a fuel cell, a memory, an electrochemical reactor, a supercapacitor, a biosensor and a medical device thereof such as artificial pancreas, and a sensor such as detector of redox reactant.Type: ApplicationFiled: July 23, 2009Publication date: May 26, 2011Inventor: Siu-Tung Yau
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Publication number: 20090152129Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.Type: ApplicationFiled: November 7, 2008Publication date: June 18, 2009Inventor: Siu-Tung Yau
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Publication number: 20090011295Abstract: The invention provides the use of silicon particles as redox catalyst, an electrochemical device and method thereof. As electrocatalyst, the silicon particles catalyze a redox reaction such as oxidization of the redox reactant such as renewable fuels e.g. methanol, ethanol and glucose. The device such as a fuel cell comprises a redox reactant and a catalytic composition comprising silicon nanoparticles. The silicon particles catalyze the redox reaction on an electrode such as anode in the device. In preferred embodiments, the electrocatalysis is dramatically improved under low illuminance such as in darkness. The invention can be widely used in applications related to for example a fuel cell, a sensor, an electrochemical reactor, and a memory.Type: ApplicationFiled: May 21, 2008Publication date: January 8, 2009Inventors: Siu-Tung Yau, Munir H. Nayfeh, Gang Wang