Patents by Inventor Siu Wai TSANG

Siu Wai TSANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10351500
    Abstract: The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 16, 2019
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Patent number: 10188590
    Abstract: The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: January 29, 2019
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yu Zhu
  • Publication number: 20180319729
    Abstract: The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 8, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG
  • Publication number: 20180228709
    Abstract: The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Application
    Filed: March 16, 2018
    Publication date: August 16, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG, Yu ZHU
  • Patent number: 10017442
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 10, 2018
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Publication number: 20180118647
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Hongjie ZHANG, Siu Wai TSANG
  • Patent number: 9956152
    Abstract: A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 1, 2018
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yu Zhu
  • Publication number: 20180085344
    Abstract: The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 29, 2018
    Inventors: Hongjie ZHANG, Man Shing Ricky WONG, Lei GUO, Siu Wai TSANG, Kanglun LIU, Tongxin ZHANG
  • Patent number: 9877931
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 30, 2018
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yegao Chen
  • Patent number: 9795589
    Abstract: The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: October 24, 2017
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Man Shing Ricky Wong, Lei Guo, Siu Wai Tsang, Kanglun Liu, Tongxin Zhang
  • Publication number: 20170290782
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 12, 2017
    Inventors: Hongjie ZHANG, Siu Wai TSANG, Yegao CHEN
  • Patent number: 9738581
    Abstract: A polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 22, 2017
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yegao Chen
  • Publication number: 20170057896
    Abstract: A polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Inventors: Hongjie ZHANG, Siu Wai TSANG, Yegao CHEN
  • Publication number: 20170057906
    Abstract: A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Application
    Filed: November 16, 2016
    Publication date: March 2, 2017
    Inventors: Hongjie ZHANG, Siu Wai TSANG, Yu ZHU
  • Patent number: 9526706
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: December 27, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Aiping Lu, Albert Sun-Chi Chan
  • Publication number: 20160367498
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 22, 2016
    Inventors: Zhaoxiang BIAN, Siu Wai TSANG, Hongjie ZHANG, Aiping LU, Albert Sun-Chi CHAN
  • Patent number: 9260466
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: February 16, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Patent number: 9044502
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: June 2, 2015
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20150079128
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Application
    Filed: September 18, 2013
    Publication date: March 19, 2015
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20140348965
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 27, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang