Abstract: A technique facilitates deployment of open hole gravel packing equipment and sand control equipment downhole in a single trip. According to an embodiment, the technique utilizes a pipe string, e.g. a workstring or a drill string, for use in an open hole gravel packing operation. The pipe string is equipped with a sand control system having at least one filtration medium, Additionally, the pipe string comprises a valve and a valve actuation device. The valve actuation device is capable of being remotely activated in a manner allowing setting of one or more packers downhole without blocking subsequent flow through the pipe string.

Abstract: A technique facilitates actuation of a downhole device, such as an isolation valve. According to an embodiment, the downhole device may be in the form of an isolation valve member, e.g. a ball valve element, actuated between positions by a mechanical section which may comprise a shifting linkage. Actuation of the mechanical section, and thus actuation of the isolation valve member, is achieved by a trip saver section controlled according to a pressure signature which may be applied from a suitable location, e.g. from the surface. The trip saver section comprises a housing having an internal actuation piston coupled with the mechanical section. The trip saver section further comprises a pilot piston and a plurality of chambers formed in a wall of the housing and arranged to enable shifting of the actuation piston in response to a predetermined series of pressure pulses or other suitable pressure signature.

Abstract: Embodiments of the disclosure provide for searching a graph database configurable via an extensible object model. Such embodiments enable streaming results data in response to receiving a structured search criteria data object. Some embodiments receive a request comprising a structured search criteria data object at an application programming interface (API) endpoint, wherein the structured search criteria data object is not directly consumable to query the graph database, convert the structured search criteria data object into at least one query statement, wherein the structured search criteria data object is converted using data query translation library code, and fetch a results data stream from the graph database by causing execution of the at least one query statement.

Abstract: A technique facilitates actuation of a downhole device, such as an isolation valve. According to an embodiment, the downhole device may be in the form of an isolation valve member, e.g. a ball valve element, actuated between positions by a mechanical section which may comprise a shifting linkage. Actuation of the mechanical section, and thus actuation of the isolation valve member, is achieved by a trip saver section controlled according to a pressure signature which may be applied from a suitable location, e.g. from the surface. The trip saver section comprises a housing having an internal actuation piston coupled with the mechanical section. The trip saver section further comprises a pilot piston and a plurality of chambers formed in a wall of the housing and arranged to enable shifting of the actuation piston in response to a predetermined series of pressure pulses or other suitable pressure signature.

Abstract: A technique facilitates actuation of a downhole device, such as an isolation valve. According to an embodiment, the downhole device may be in the form of an isolation valve member, e.g. a ball valve element, actuated between positions by a mechanical section which may comprise a shifting linkage. Actuation of the mechanical section, and thus actuation of the isolation valve member, is achieved by a trip saver section controlled according to a pressure signature which may be applied from a suitable location, e.g. from the surface. The trip saver section comprises a housing having an internal actuation piston coupled with the mechanical section. The trip saver section further comprises a pilot piston and a plurality of chambers formed in a wall of the housing and arranged to enable shifting of the actuation piston in response to a predetermined series of pressure pulses or other suitable pressure signature.

Abstract: A system includes a downhole valve, a pressure gauge mounted on the downhole valve, and a power source for powering the pressure gauge. The pressure gauge is programmed to interpret a pressure command characterized by at least two variables of a pressure signal to open the downhole valve.

Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), (III) and (IV), or of Table 1 or Table 4), and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and kits comprising the same. The compounds provided herein are activin receptor-like kinase (e.g., ALK-5) inhibitors and are, therefore, useful, for example, for treating and/or preventing diseases (e.g., proliferative diseases, such as cancer) in a subject, inhibiting tumor growth in a subject, or inhibiting the activity of an activin receptor-like kinase (e.g., ALK-5) in vitro or in vivo. Also provided herein are methods and synthetic intermediates useful in the preparation of compounds described herein.

Abstract: An isolation valve system includes a well string having an isolation valve including a ball rotatably mounted to a pair of inserts for rotation about a fixed axis, an arm coupled to the ball at a position offset from the fixed axis, and a mandrel connected to an actuation end of the arm, the mandrel and the actuation end of the arm being disposed uphole of the ball. Via the actuation end of the arm, the mandrel forces rotation of the ball from a closed position to an open position by moving in a linear direction away from the ball, which allows flow of fluid along a through hole of the ball.

Abstract: A method, a device, and a non-transitory storage medium are described in which a monitoring event handling service is provided. The service may include a non-stand-alone core device subscribing to a registration status for an end device with a stand-alone core device. The service may also include the non-stand-alone core device subscribing to a monitoring event service with the stand-alone core device on behalf of another non-stand-alone core network device. The stand-alone core device may monitor an event when the end device is stand-alone registered and may notify the non-stand-alone core device when the event occurs. The service may include the non-stand-alone core device notifying the other non-stand-alone core device when the event occurs.

Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), (III) and (IV), or of Table 1 or Table 4), and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and kits comprising the same. The compounds provided herein are activin receptor-like kinase (e.g., ALK-5) inhibitors and are, therefore, useful, for example, for treating and/or preventing diseases (e.g., proliferative diseases, such as cancer) in a subject, inhibiting tumor growth in a subject, or inhibiting the activity of an activin receptor-like kinase (e.g., ALK-5) in vitro or in vivo. Also provided herein are methods and synthetic intermediates useful in the preparation of compounds described herein.

Abstract: The present invention provides substantially pure venetoclax, process for the preparation of substantially pure venetoclax and pharmaceutical formulation of substantially pure venetoclax. In another aspect present invention provides amorphous venetoclax in a free drug particulate form, process for the preparation of amorphous venetoclax in a free drug particulate form and pharmaceutical formulation of amorphous venetoclax in a free drug particulate form.

Abstract: The present application relates to a process for the preparation of midostaurin by controlling critical impurities or by-products which in turn lead to increase in the overall yield and purity. The present application also provides midostaurin having less than 0.15% or substantially free or free of one or more impurities.

Abstract: A technique facilitates actuation of a downhole device, such as an isolation valve. According to an embodiment, the downhole device may be in the form of an isolation valve member, e.g. a ball valve element, actuated between positions by a mechanical section which may comprise a shifting linkage Actuation of the mechanical section, and thus actuation of the isolation valve member, is achieved by a trip saver section controlled according to a pressure signature which may be applied from a suitable location, e.g. from the surface. The trip saver section comprises a housing having an internal actuation piston coupled with the mechanical section. The trip saver section further comprises a pilot piston and a plurality of chambers formed in a wall of the housing and arranged to enable shifting of the actuation piston in response to a predetermined series of pressure pulses or other suitable pressure signature.

Abstract: The present invention relates to a process for the preparation of Molnupiravir. The present invention also relates to an improved and commercially viable process for preparation of Molnupiravir with high yield and purity.

Abstract: An isolation valve system includes a well string having an isolation valve including a ball rotatably mounted to a pair of inserts for rotation about a fixed axis, an arm coupled to the ball at a position offset from the fixed axis, and a mandrel connected to an actuation end of the arm, the mandrel and the actuation end of the arm being disposed uphole of the ball. Via the actuation end of the arm, the mandrel forces rotation of the ball from a closed position to an open position by moving in a linear direction away from the ball, which allows flow of fluid along a through hole of the ball.

Abstract: Disclosed examples include a method and automated test system for testing an ADC. The method includes computing an ADC noise value based on a first set of data values sampled while the ADC input terminals are shorted, computing a first system noise value based on a second set of data values sampled while a test circuit signal source applies zero volts to the ADC through a signal chain, computing a signal chain noise value based on the first system noise value and the ADC noise value, computing a measured SNR value based on a third set of data values sampled while the test circuit signal source applies a non-zero source voltage signal to the signal chain, computing a second system noise value based on the measured SNR value, and computing an ADC SNR value based on the second system noise value and the signal chain noise value.

Abstract: Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic schemes are also disclosed.

Abstract: Aspects of the present application relates to co-crystal of carfilzomib with maleic acid, process for the preparation of co-crystal of carfilzomib with maleic acid, process for the preparation of pure carfilzomib from co-crystal of carfilzomib with maleic acid and process for the preparation of amorphous carfilzomib.

Abstract: Disclosed examples include a method and automated test system for testing an ADC. The method includes computing an ADC noise value based on a first set of data values sampled while the ADC input terminals are shorted, computing a first system noise value based on a second set of data values sampled while a test circuit signal source applies zero volts to the ADC through a signal chain, computing a signal chain noise value based on the first system noise value and the ADC noise value, computing a measured SNR value based on a third set of data values sampled while the test circuit signal source applies a non-zero source voltage signal to the signal chain, computing a second system noise value based on the measured SNR value, and computing an ADC SNR value based on the second system noise value and the signal chain noise value.

Abstract: Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic schemes are also disclosed.