Patents by Inventor Sivan Harel

Sivan Harel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING OR PREVENTING ALLERGIC ASTHMA BY ADMINISTERING AN IL-33 ANTAGONIST AND/OR AN IL-4R ANTAGONIST
    Publication number: 20230340101
    Abstract: Methods for treating or preventing allergic asthma and associated conditions in a subject are provided. Certain methods disclosed here comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-33 (IL-33) antagonist, such as an anti-IL-33 antibody. Other methods disclosed here comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4R (IL-4R) antagonist, such as an anti-IL-4R antibody. Still other methods disclosed here comprise administering to a subject in need thereof a first therapeutic composition comprising an interleukin-33 (IL-33) antagonist, such as an anti-IL-33 antibody, and a second therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody. Allergic asthma-associated signature genes are provided. Methods of altering (e.g.
    Type: Application
    Filed: December 22, 2020
    Publication date: October 26, 2023
    Inventors: Helene GOULAOUIC, El-Bdaoui HADDAD, Sara HAMON, Sivan HAREL, Georgios KALLIOLIAS, Marcella RUDDY
  • Transcriptome Analysis For Treating Inflammation
    Publication number: 20230340601
    Abstract: The present disclosure provides methods of identifying a disease or condition suitable for treatment with dupilumab. The present disclosure also provides methods of identifying a subject having a disease or condition suitable for treatment with dupilumab. The present disclosure also provides methods of carrying out a clinical trial for dupilumab treatment of a disease or condition.
    Type: Application
    Filed: April 25, 2023
    Publication date: October 26, 2023
    Inventors: Wei Keat Lim, Kaitlyn Gayvert, Sivan Harel, Jennifer Davidson Hamilton, Sara Hamon, Matthew F. Wipperman
  • METHODS FOR TREATING COPD BY ADMINISTERING AN IL-33 ANTAGONIST
    Publication number: 20210230265
    Abstract: Methods for treating or preventing COPD and associated conditions in a patient are provided. Methods comprising administering to a subject in need thereof a therapeutic composition comprising an interleukin-33 (IL-33) antagonist, such as an anti-IL-33 antibody or antigen-binding fragment thereof, are provided.
    Type: Application
    Filed: December 4, 2020
    Publication date: July 29, 2021
    Inventors: Raolat Abdulai, Alexander Boddy, Deborah Dukovic, Helene Goulaouic, Andreas Jessel, Xiaodong Luo, Heribert Staudinger, Ariel Teper, Marcella Ruddy, Nikhil Amin, Sivan Harel, Chad Nivens
  • METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST
    Publication number: 20210032354
    Abstract: Methods for treating or preventing asthma (e.g., allergic asthma, asthma associated with allergic bronchopulmonary aspergillosis (ABPA), moderate-to-severe asthma, persistent asthma or the like) and associated conditions (e.g., ABPA, ABPA comorbid with asthma, ABPA comorbid with cystic fibrosis (CF), ABPA comorbid with asthma and CF) in a subject are provided. Methods comprising administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof, are provided.
    Type: Application
    Filed: July 15, 2020
    Publication date: February 4, 2021
    Inventors: Heribert Staudinger, Ariel Teper, Nikhil Amin, Sivan Harel, Neil Graham
  • METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-33 ANTAGONIST
    Publication number: 20210000949
    Abstract: The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-33 (IL-33) antagonist, such as an anti-IL-33 antibody. The methods featured in the invention further comprise administering to a subject in need thereof a first therapeutic composition comprising an interleukin-33 (IL-33) antagonist, such as an anti-IL-33 antibody, and a second therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.
    Type: Application
    Filed: April 30, 2020
    Publication date: January 7, 2021
    Inventors: Helene Goulaouic, Andreas Jessel, Raolat Abdulai, Ariel Teper, Marcella Ruddy, Nikhil Amin, Sivan Harel, Weronika Szafran, John Huber, Joanna Pols