Abstract: A device for monitoring bolus doses of a medicament administered by a drug delivery device, such as a wearable infusion device, includes a housing and a sensor disposed therein, where the sensor detects a signal generated by the wearable infusion device upon administration of a dose of a medicament. The device may also be provided as a system with the drug delivery device and a user device, where the user device gathers data regarding use of the drug delivery device and doses of medicament administered.

Abstract: The present invention employs a self-ligating orthodontic bracket comprising a body having a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body; an arch wire slot extending mesially-distally across the body and between the gingival and occlusal tie wings to accommodate an arch wire; a free-sliding, controlled-locking, or pivoting clip wherein the clip allows placement and removal of the arch wire when in the open position and prevents the displacement of the arch wire from the bracket member when in the closed position.

Abstract: A package (10, 10?) for securing an orthodontic bracket (30) includes a pocket (12, 71) having an inclined floor (40, 70) and a mechanical locking device (51, 71) for removably holding the bracket (30) in the pocket (12, 71) until it is intentionally removed by a user.

Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.

Abstract: An orthodontic bracket (10) of the type to be bonded to a patient's tooth has a base (22) and a side proximal (20) to a patient's tooth when positioned thereon. Proximal side (20) is provided with flow path regulating structures (30) that define a prescribed flow path for bonding material (32) when the bracket (10) is pressed to a tooth. Areas (40, 50) are provided as catchments for excess bonding material to thereby reduce the occurrence of flash.

Abstract: The present invention employs a self-ligating orthodontic bracket comprising a body having a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body; an arch wire slot extending mesially-distally across the body and between the gingival and occlusal tie wings to accommodate an arch wire; a free-sliding, controlled-locking, or pivoting clip wherein the clip allows placement and removal of the arch wire when in the open position and prevents the displacement of the arch wire from the bracket member when in the closed position.

Abstract: The present invention employs a self-ligating orthodontic bracket comprising a body having a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body; an arch wire slot extending mesially-distally across the body and between the gingival and occlusal tie wings to accommodate an arch wire; a free-sliding, controlled-locking, or pivoting clip wherein the clip allows placement and removal of the arch wire when in the open position and prevents the displacement of the arch wire from the bracket member when in the closed position.

Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.

Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.

Abstract: The present invention employs a self-ligating orthodontic bracket comprising a body having a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body; an arch wire slot extending mesially-distally across the body and between the gingival and occlusal tie wings to accommodate an arch wire; a free-sliding, controlled-locking, or pivoting clip wherein the clip allows placement and removal of the arch wire when in the open position and prevents the displacement of the arch wire from the bracket member when in the closed position.

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Abstract: Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

Abstract: A sensor system for use with an infusion system may include at least one sensor disposed within a catheter, the at least one sensor comprising at least one of an optical sensor, an electrical sensor or a chemical/biochemical sensor. The sensor system may instead include a sample cell that is in fluid communication with the infusion system, which sample cell may be used with an analyzer to determine a patient's condition. The sensor system may be integrated with a control system for an infusion pump to control operation of the pump.

Abstract: The present invention is a flexible hybrid biofuel cell power strip for use in low power applications (less than one Watt) such as trickle charging to extend the charge of conventional batteries or to power devices such as microsensors, micropumps and miniaturized medial devices. The power strip anode comprises carbon nanotubes (CNTs) that transfer electrons directly from the active center of an oxidation-reduction (redox) enzyme to a flexible, conductive anode substrate. This allows the building of surface architectures with pore structures customized for specific applications and enzyme substrate-containing media. The cathode comprises a catalytic layer of transition metal nanoparticle catalyst in contact with air or other source of oxygen. The flexibility of the power strip allows it to be shaped into a wide variety of conformations and applications, including attachment to or implantation within living organisms.

Abstract: The present invention is a simulation-based method for rapidly designing, evaluating, and/or optimizing a microfluidic system or biochip. The method provides an environment for schematic generation, system layout, problem setup, simulation, and post-processing. The method comprises a system solver used to simulate microfluidic processes such as pressure driven and electroosmotic flows, analytes dispersion, separation, and mixing, and biochemical reactions. The system solver uses a mixed methodology approach that enables the operation of complete, complex microfluidic systems to be simulated rapidly and iteratively.