Abstract: Provided herein are compositions and methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for mutational analysis in research, diagnostics, and treatment. Such methods and compositions facilitate highly accurate amplification of target (or “template”) nucleic acids, which increases accuracy and sensitivity of downstream applications, such as Next-Generation Sequencing.

Abstract: A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity. Error correction code associated with each page of a sound sample is stored with the sound sample and is retrieved with the sound sample during playback to thereby increase the overall sample retrieval rate.

Abstract: A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity. Error correction code associated with each page of a sound sample is stored with the sound sample and is retrieved with the sound sample during playback to thereby increase the overall sample retrieval rate.

Abstract: A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity.

Abstract: A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity.

Abstract: A system for updating a control coefficient to a target value during a prescribed number of periodic incremental update increments. The system divides the desired change in the value of the coefficient by the number of update increments. Specifically, the number of increments by the number of increments is limited to powers of two, so that the division can be accomplished simply by demarking the change in value according to the portion of number of increments, thereby separating the change into a quotient and a remainder. The value of each update increment is nominally equal to the quotient, with the remainder being distributed relatively evenly by adding one to selected updates.