Patents by Inventor Siyan Zhang

Siyan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered potent cytotoxic stapled BH3 peptides
    Patent number: 11312756
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: April 26, 2022
    Assignee: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • NOVEL ENGINEERED POTENT CYTOTOXIC STAPLED BH3 PEPTIDES
    Publication number: 20190309038
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: May 3, 2019
    Publication date: October 10, 2019
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Engineered potent cytotoxic stapled BH3 peptides
    Patent number: 10344064
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: July 9, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: A. James Link, Siyan Zhang
  • INHIBITORY RNA FOR ENHANCED PROTEIN PRODUCTION IN RECOMBINANT MAMMALIAN CELLS
    Publication number: 20170226550
    Abstract: The invention provides methods and compositions for improving production of exogenous polypeptides in large scale culture of mammalian host cells. The methods and compositions utilize RNA interference to inhibit expression of one or more specific host cell proteins. The present invention is based on the identification of specific mammalian genes and sequences therein that are useful as RNAi targets to enhance the production of exogenous proteins in mammalian cell culture.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 10, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jianxin Ye, Krista Alvin, Siyan Zhang
  • NOVEL ENGINEERED POTENT CYTOTOXIC STAPLED BH3 PEPTIDES
    Publication number: 20160376336
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: September 14, 2016
    Publication date: December 29, 2016
    Applicant: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Engineered potent cytotoxic stapled BH3 peptides
    Patent number: 9464125
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: October 11, 2016
    Assignee: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • NOVEL ENGINEERED POTENT CYTOTOXIC STAPLED BH3 PEPTIDES
    Publication number: 20150045310
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Application
    Filed: February 4, 2013
    Publication date: February 12, 2015
    Inventors: A. James Link, Siyan Zhang