Patents by Inventor Siyang Zheng
Siyang Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210302287Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.Type: ApplicationFiled: April 21, 2021Publication date: September 30, 2021Inventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
-
Publication number: 20210212955Abstract: The present invention relates to compositions and methods for delivery of therapeutic agent. In certain aspects, the invention comprises a metal-organic framework nanoparticle encapsulating a protein. In some aspects, the metal-organic framework nanoparticle encapsulating a protein is coated with an extracellular vesicle membrane.Type: ApplicationFiled: May 28, 2019Publication date: July 15, 2021Inventors: Siyang ZHENG, Cheng GONG
-
Patent number: 11022529Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.Type: GrantFiled: February 7, 2020Date of Patent: June 1, 2021Assignee: The Penn State Research FoundationInventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
-
Publication number: 20200284706Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.Type: ApplicationFiled: February 7, 2020Publication date: September 10, 2020Inventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
-
Patent number: 10598575Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.Type: GrantFiled: July 18, 2016Date of Patent: March 24, 2020Assignee: The Penn State Research FoundationInventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
-
Patent number: 9757729Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: November 18, 2016Date of Patent: September 12, 2017Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Publication number: 20170136463Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: November 18, 2016Publication date: May 18, 2017Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Publication number: 20170038285Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.Type: ApplicationFiled: July 18, 2016Publication date: February 9, 2017Inventors: Siyang Zheng, Mauricio Terrones, Yin-Ting Yeh, Yi Tang, Huaguang Lu, Nestor Perea Lopez, Yiqiu Xia
-
Patent number: 9547163Abstract: We present a method for parallel axial imaging, or z-microscopy, utilizing an array of tilted micro mirrors arranged along the axial direction. Image signals emitted from different axial positions can be orthogonally reflected by the corresponding micro mirrors and spatially separated for parallel detection, essentially converting the more challenging axial imaging to a lateral imaging problem. Each micro mirror also provides optical sectioning capability due to its finite dimension.Type: GrantFiled: November 29, 2013Date of Patent: January 17, 2017Assignee: The Penn State Research FoundationInventors: Zhiwen Liu, Chuan Yang, Kebin Shi, Mingda Zhou, Siyang Zheng, Shizhuo Yin
-
Patent number: 9535059Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: November 3, 2015Date of Patent: January 3, 2017Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Patent number: 9370736Abstract: A filtering device includes a housing and one or more flexible filter arrays. The flexible filter arrays can be coupled to the housing. Each flexible filter array can include a plurality of members and one or more support members. The plurality of members each can have a proximal and a distal end, the plurality of members being spaced apart by a predetermined distance. The one or more support members can be coupled to one or more of the plurality of members. Each of the plurality of members can be configured to deflect relative to the one or more support members.Type: GrantFiled: January 17, 2013Date of Patent: June 21, 2016Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Siyang Zheng, Ramdane Harouaka, Mingda Zhou, Yin-Ting Yeh
-
Publication number: 20160131640Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: November 3, 2015Publication date: May 12, 2016Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Patent number: 9234884Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: April 13, 2015Date of Patent: January 12, 2016Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Publication number: 20150369781Abstract: A micro-electro-mechanical system (MEMS) flow control chip that can control the flow of gas and be configured to operate in a gas chromatography system are disclosed. The MEMS flow control chip can include at least one inlet port in the chip, at least one outlet port in the chip, at least one flow channel between the inlet and outlet ports, and at least one pneumatic valve in the chip for controlling a flow of gas through the flow channel and between the inlet port and outlet ports. Advantageously, the MEMS flow control chip can be positioned in an oven of the a gas chromatography system and have a temperature approximately the same as one or more chromatographic columns of the system.Type: ApplicationFiled: June 8, 2015Publication date: December 24, 2015Inventors: Siyang ZHENG, Mingda ZHOU, Andrew J. MYRICK
-
Publication number: 20150309011Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: April 13, 2015Publication date: October 29, 2015Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
-
Patent number: 9029158Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: June 4, 2014Date of Patent: May 12, 2015Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
-
Publication number: 20140377742Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: June 4, 2014Publication date: December 25, 2014Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
-
Patent number: 8815092Abstract: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.Type: GrantFiled: December 29, 2011Date of Patent: August 26, 2014Assignees: California Institute of Technology, University of Southern CaliforniaInventors: Siyang Zheng, Richard Cote, Henry Lin, Bo Lu, Yu-Chong Tai
-
Publication number: 20140146159Abstract: We present a method for parallel axial imaging, or z-microscopy, utilizing an array of tilted micro mirrors arranged along the axial direction. Image signals emitted from different axial positions can be orthogonally reflected by the corresponding micro mirrors and spatially separated for parallel detection, essentially converting the more challenging axial imaging to a lateral imaging problem. Each micro mirror also provides optical sectioning capability due to its finite dimension.Type: ApplicationFiled: November 29, 2013Publication date: May 29, 2014Applicant: The Penn State Research FoundationInventors: Zhiwen Liu, Chuan Yang, Kebin Shi, Mingda Zhou, Siyang Zheng, Shizhuo Yin
-
Publication number: 20130180909Abstract: A filtering device includes a housing and one or more flexible filter arrays. The flexible filter arrays can be coupled to the housing. Each flexible filter array can include a plurality of members and one or more support members. The plurality of members each can have a proximal and a distal end, the plurality of members being spaced apart by a predetermined distance. The one or more support members can be coupled to one or more of the plurality of members. Each of the plurality of members can be configured to deflect relative to the one or more support members.Type: ApplicationFiled: January 17, 2013Publication date: July 18, 2013Applicant: The Penn State Research FoundationInventors: Siyang Zheng, Ramdane Harouaka, Mingda Zhou, Yin-Ting Yeh