Abstract: An underneath large-capacity single-gas-pump foam generating device includes a liquid replenishment mechanism and a foam generating mechanism. The liquid replenishment mechanism includes a liquid replenishment groove and a liquid replenishment bottle. The liquid replenishment bottle has a bottle opening sleeved in the liquid replenishment groove. The foam generating mechanism includes a gas supply pump unit, a gas mixing groove cavity, a gas-liquid mixing structure, a gas inlet and a vent valve structure. A lower portion of the gas mixing groove cavity is communicated with a lower portion of the liquid replenishment groove, a liquid replenishment one-way valve is arranged between the gas mixing groove cavity and the liquid replenishment groove. The gas-liquid mixing structure is provided with a liquid outlet channel, a gas outlet channel and a mixing channel, an inlet end of the liquid outlet channel extends downwardly into a bottom portion of the gas mixing groove cavity.

Abstract: The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions, regulating cellular glucose uptake and homeostasis, inducing labour and lactation, and other disorders or conditions wherein excessive or undesirable IRAP activity is implicated.