Abstract: The present invention belongs to the technical field of biomedicine, and specifically relates to an extracellular cyclophilin inhibitor and the use thereof, wherein the structural general formula of the extracellular cyclophilin inhibitor of the present invention is as shown in formula (I). According to the present invention, a group capable of reacting with sulfhydryl of cysteine at a specific site on blood albumin is extracted by means of a side chain of a new cyclosporin derivative, and a drug conjugate is rapidly formed after same enters the body, which can effectively restrict the drug to the extracellular area and form targeted inhibition of extracellular cyclophilin, thereby achieving the aim of treating diseases associated therewith.

Abstract: Provided is a bacterial cellulose-producing Komagataeibacter europaeus strain FMES and use thereof. The strain FMES is deposited in the China Center for Type Culture Collection (CCTCC) with a deposit number of CCTCC NO: M20221627. The strain FMES is isolated from traditional vinegar brewing and can efficiently produce bacterial cellulose through static culture. The strain FMES can also be used to produce a novel, green, and non-toxic degradable biotextile. Therefore, the strain FMES is expected to replace leather, textiles, and films derived from animals, plants, and petrochemicals, and shows a potential to serve as a sustainable alternative of the textiles.

Abstract: Methods, systems, and devices for data management are described. A self-executing program of a blockchain network (e.g., blockchain distributed data store) may receive, from a client application, a first request to mint an identity attestation token for a user. The first request may include an indication of a wallet address for the user. The self-executing program may generate the identity attestation token that is indicative of first identity information, for the user, that is stored in an off-chain data source and broadcast a message that is configured to transfer the identity attestation token to the wallet address for the user. The self-executing program may receive, from a second application, a request for the first identity information for the user and send, to the second client application after receiving the request, a second message that includes information indicative of the off-chain data source.

Abstract: A method of selectively controlling materials structure in solution based chemical synthesis and deposition of materials by controlling input energy from pulsed energy source includes determining solution conditions, searching and/or determining energy barrier(s) of a desired materials structure formation, applying precursor solution with selected solution condition onto a substrate, and applying determined input energy from a pulsed energy source with a selected condition to the substrate, thereby nucleating and growing the crystal.

Abstract: The present disclosure providing a geological sampling backpack drilling machine includes a housing, a drilling device movably received in the housing, a seat arranged on the housing, and a bracket detachably connected to the housing via a limiting rotator, with an angle between the bracket and the housing being variable; the seat arranged between a tip of a drilling rod and the bracket, and rotating around the drilling rod as an axis thereof; a rotating member arranged on a surface of the seat and surrounding around the drilling rod to detachably connect with a supporting post, both the supporting post and the bracket cooperatively supporting the drilling device; the drilling rod passing through the housing and the seat; both the bracket and the supporting post supporting the drilling device that is obliquely drilled and the housing for enabling the drilling device to stably drill at an inclined state.

Abstract: It is disclosed a motor thermal protection device and operation method thereof. The motor thermal protection device utilizes a power supply of a motor for power supplying and comprises: a capacitor timing circuit, configured to time after the motor is powered off; a power-off time determining unit, configured to perform a reading operation of reading an output voltage of the capacitor timing circuit after the motor is powered on, and determine a power-off time from when the motor is powered off to when the motor is powered on according to the output voltage; and a heat accumulation calculating unit, configured to calculate a remaining heat accumulation when the motor is powered on according to the power-off time and a heat accumulation when the motor is powered off.

Abstract: The present disclosure provides a method and device for constructing an autism spectrum disorder (ASD) risk prediction model. The method includes: establishing a first data table and a second data table based on case information of a sample set, obtaining a first grouped table set and a second grouped table set according to a preset characteristic arrangement rule and marker grouping rule, training data based on a random forest machine learning algorithm, and importing test data to obtain a first best characteristic combination and a second characteristic combination; and obtaining a first model based on the first best characteristic combination, stratified sampling of the first data table, and the random forest machine learning algorithm, obtaining a second model based on the second best characteristic combination, stratified sampling of the second data table, and the random forest machine learning algorithm, and performing combination to construct an ASD risk prediction model.

Abstract: The present invention provides A magnesium oxide whisker in-situ formed MA spinel-reinforced magnesium oxide-based ceramic foam filter and a method for preparing the same. The method comprising: 1) preparing a ceramic slurry having a solid content of 60%-70% by dosing 15%-25% by mass of a nanometer alumina sol, 0.8%-1.5% by mass of a rheological agent, and the balance magnesium oxide ceramic powder comprising magnesium oxide whiskers, and then adding deionized water and ball milling to mix until uniform, and then vacuum degassing the mixture; 2) soaking a polyurethane foam template into the ceramic slurry, squeezing by a roller press the polyurethane foam template to remove redundant slurry therein to make a biscuit, and drying the biscuit by heating it to 80° C.-1200° C.; 3) putting the dried biscuit into a sintering furnace, elevating the temperature to 1400° C.-1600° C.

Abstract: A method of selectively controlling materials structure in solution based chemical synthesis and deposition of materials by controlling input energy from pulsed energy source includes determining solution conditions, searching and/or determining energy barrier(s) of a desired materials structure formation, applying precursor solution with selected solution condition onto a substrate, and applying determined input energy from a pulsed energy source with a selected condition to the substrate, thereby nucleating and growing the crystal.

Abstract: Methods, devices, and non-transitory computer-readable storage mediums are provided for distributing red envelops. The method includes following steps: generating red envelopes based on a user instruction; receiving a first request for accessing the red envelopes in response to a delay condition being fulfilled; calculating one or more amounts based on an audience number of online audiences at current moment; and placing the one or more amounts at a preset position of a container for displaying.

Abstract: A method of selectively controlling materials structure in solution based chemical synthesis and deposition of materials by controlling input energy from pulsed energy source includes determining solution conditions, searching and/or determining energy barrier(s) of a desired materials structure formation, applying precursor solution with selected solution condition onto a substrate, and applying determined input energy from a pulsed energy source with a selected condition to the substrate, thereby nucleating and growing the crystal.

Abstract: The control device for an internal combustion engine disclosed in the present application is a control device that determines the presence or absence of misfire based on an angle detection cycle calculated from an output signal of an angle sensor, the control device includes an arithmetic processing device and a storage device, the control device is configured so that the storage device stores the angle detection cycle calculated in a misfire detection threshold value comparison section after the reference angle section as a threshold value comparison target cycle and is configured such that the arithmetic processing device determines the presence or absence of misfire based on the misfire detection threshold value cycle calculated based on the reference detection cycle and the threshold value comparison target cycle, thereby it becomes possible to accurately determine the presence or absence of misfire in the control device for the internal combustion engine.

Abstract: A spinel-reinforced magnesium oxide-based foam ceramic filter that is obtained by coating onto a polyurethane foam carrier a slurry of light calcined magnesium oxide-based ceramic comprising a nanometer lanthanum oxide sintering aid, and then drying and sintering. A method for preparing the foam ceramic filter comprising: 1) preparing a ceramic slurry having a solid content of 60%-70% by dosing 15%-25% by mass of a nanometer alumina sol, 0.8%-1.5% by mass of a rheological agent, and the balance magnesium oxide ceramic powder comprising a nanometer lanthanum oxide sintering aid, and then adding absolute ethanol and ball milling to mix until uniform; 2) soaking a polyurethane foam template into the ceramic slurry, squeezing by a roller press the polyurethane foam template to remove redundant slurry therein to make a biscuit, and then removing the ethanol solvent in a ventilation chamber at a temperature of 40° C.-50° C.

Abstract: It is disclosed a motor thermal protection device and operation method thereof. The motor thermal protection device utilizes a power supply of a motor for power supplying and comprises: a capacitor timing circuit, configured to time after the motor is powered off; a power-off time determining unit, configured to perform a reading operation of reading an output voltage of the capacitor timing circuit after the motor is powered on, and determine a power-off time from when the motor is powered off to when the motor is powered on according to the output voltage; and a heat accumulation calculating unit, configured to calculate a remaining heat accumulation when the motor is powered on according to the power-off time and a heat accumulation when the motor is powered off.

Abstract: Methods, devices, and non-transitory computer-readable storage mediums are provided for distributing red envelops. The method includes following steps: generating red envelopes based on a user instruction; receiving a first request for accessing the red envelopes in response to a delay condition being fulfilled; calculating one or more amounts based on an audience number of online audiences at current moment; and placing the one or more amounts at a preset position of a container for displaying.

Abstract: The present application disclose a method, system, and an intelligent terminal for distributing random data. The method comprises the following steps: obtaining a user instruction to be executed; generating data to be shared based on the user instruction, wherein the data to be shared is conditioned on a delay; detecting whether an ended condition of the delay is fulfilled; and receiving a first request for accessing the data to be shared in response to that the ended condition is fulfilled.

Abstract: A method of selectively controlling materials structure in solution based chemical synthesis and deposition of materials by controlling input energy from pulsed energy source includes determining solution conditions, searching and/or determining energy barrier(s) of a desired materials structure formation, applying precursor solution with selected solution condition onto a substrate, and applying determined input energy from a pulsed energy source with a selected condition to the substrate, thereby nucleating and growing the crystal.