Patents by Inventor Siyu Tu
Siyu Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230174490Abstract: The present disclosure relates to improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates.Type: ApplicationFiled: March 17, 2021Publication date: June 8, 2023Applicant: CORTEVA AGRISCIENCE LLCInventors: CHUNMING ZHANG, SIYU TU, RONALD B. LENG, NICHOLAS IRVINE, ABRAHAM SCHUITMAN, AARON SHINKLE, JAYACHANDRAN DEVARAJ, CHENGLI ZU
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Publication number: 20220411375Abstract: The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.Type: ApplicationFiled: October 15, 2020Publication date: December 29, 2022Applicant: CORTEVA AGRISCIENCE LLCInventors: NICHOLAS R. BABIJ, ELIZABETH O. MCCUSKER, GREGORY T. WHITEKER, NEERAJ SANE, SIYU TU, XIAOYONG LI, DANIEL W. KLOSOWSKI, PATRICK T. MCGOUGH, MENG GUO, MATTHEW ROBINSON, JEFFREY SCOTT NISSEN, TYLER DAVIS, YAN HAO
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Publication number: 20220371997Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.Type: ApplicationFiled: June 23, 2022Publication date: November 24, 2022Applicant: CORTEVA AGRISCIENCE LLCInventors: JAYACHANDRAN DEVARAJ, NUGZAR GHAVTADZE, NICHOLAS M. IRVINE, JEREMY KISTER, MELISSA LEE, RONALD B. LENG, RONGRONG [MANDY] LIN, RONG LING, NOORMOHAMED M. NIYAZ, ABRAHAM D. SCHUITMAN, AARON A. SHINKLE, SIYU TU, GREGORY T. WHITEKER, CHUNMING ZHANG
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Patent number: 11401242Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.Type: GrantFiled: September 18, 2019Date of Patent: August 2, 2022Assignee: Corteva Agriscience LLCInventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
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Publication number: 20210380613Abstract: A method for preparing phosphine-borane complexes from aryldihalophosphine includes mixing sodium borohydride, a solvent having at least 50 vol % glycol ethers, and the aryldihalophosphine to obtain a solution. The solution is maintained at a reaction temperature for a duration of time to obtain the phosphine-borane complexes. The solvent may include 1,2-dimethoxyethane and tetrahydrofuran. A ratio of tetrahydrofuran to 1,2-dimethoxyethane in the solvent may be from 0.1:1.0 to 2.5:1.0.Type: ApplicationFiled: September 18, 2019Publication date: December 9, 2021Applicant: Dow Global Technologies LLCInventors: Siyu Tu, Jessica L. Klinkenberg, Yiyong He, Xiaoyun Chen, Haoquan Li, Matthew S. Remy
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Publication number: 20210323923Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.Type: ApplicationFiled: September 18, 2019Publication date: October 21, 2021Applicant: Corteva Agriscience LLCInventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
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Patent number: 11111260Abstract: A method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane includes obtaining a solution comprising an ethereal solvent and an aluminum hydride, adding dichloro(2,4-dimethoxyphenyl)phosphine to the solution to produce 2,4-dimethoxyphenylphosphine, and reacting the 2,4-dimethoxyphenylphosphine with an acidic mixture comprising diones to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane. The solution has a temperature from IN greater than ?20 C. to 50 C. throughout the method. Another method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-tri-oxa-6-phosphaadamantane includes obtaining dichloro(2,4-dimethoxyphenyl)phosphine, forming 2,4-dimethoxyphenylphosphine by adding the dichloro(2,4-dimethoxyphenyl)phosphine to a solution comprising at least one solvent and an aluminum hydride, reacting the 2,4-dimethoxyphenylphosphine with a mixture to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane.Type: GrantFiled: March 22, 2018Date of Patent: September 7, 2021Assignee: Dow Global Technologies LLCInventors: Jessica L. Klinkenberg, John R. Briggs, Andrew M. Camelio, Robert David Grigg, Siyu Tu
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Patent number: 10570114Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: July 26, 2018Date of Patent: February 25, 2020Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
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Patent number: 10544121Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: July 26, 2018Date of Patent: January 28, 2020Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
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Publication number: 20200010494Abstract: A method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane includes obtaining a solution comprising an ethereal solvent and an aluminum hydride, adding dichloro(2,4-dimethoxyphenyl)phosphine to the solution to produce 2,4-dimethoxyphenylphosphine, and reacting the 2,4-dimethoxyphenylphosphine with an acidic mixture comprising diones to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane. The solution has a temperature from IN greater than ?20 C. to 50 C. throughout the method. Another method for forming 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-tri-oxa-6-phosphaadamantane includes obtaining dichloro(2,4-dimethoxyphenyl)phosphine, forming 2,4-dimethoxyphenylphosphine by adding the dichloro(2,4-dimethoxyphenyl)phosphine to a solution comprising at least one solvent and an aluminum hydride, reacting the 2,4-dimethoxyphenylphosphine with a mixture to produce 1,3,5,7-tetraalkyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane.Type: ApplicationFiled: March 22, 2018Publication date: January 9, 2020Applicant: Dow Global Technologies LLCInventors: Jessica L. Klinkenberg, John R. Briggs, Andrew M. Camelio, Robert David Grigg, Siyu Tu
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Publication number: 20180334444Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: July 26, 2018Publication date: November 22, 2018Applicant: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jooossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
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Publication number: 20180334445Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: July 26, 2018Publication date: November 22, 2018Applicant: Dow AgroSciences LLCInventors: Jason S. F, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
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Patent number: 10087164Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This invention was expanded to include synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: May 19, 2017Date of Patent: October 2, 2018Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
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Publication number: 20170334878Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalky and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This invention was expanded to include synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: May 19, 2017Publication date: November 23, 2017Applicant: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng