Abstract: The invention provides an exonuclease or an enzymatically active fragment thereof, said exonuclease having the amino acid sequence of SEQ ID No. 1 or an amino acid sequence which is at least about 50% identical thereto, wherein said exonuclease or enzymatically active fragment thereof (i) is substantially irreversibly inactivated by heating at a temperature of about 55° C. for 10 minutes in a buffer consisting of 10 mM Tris-HCl, pH 8.5 at 25° C., 50 mM KCl and 5 mM MgCl2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3?-5? exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used.

Abstract: A support pillow includes a flexible outer sleeve and a deformable inner cushion positioned wholly inside the outer sleeve. Both the outer sleeve and inner cushion are elongate. The outer sleeve is longer than the inner cushion and defines a pair of free end portions extending beyond the inner cushion. The inner cushion is moveable inside the outer sleeve such that the length of each of the free end portions is adjustable. A gripping device can be moved along each end portion to close the outer sleeve around the inner cushion and fix the length of the free end portion extending beyond the inner cushion. The free end portions extend far enough to enable a user to connect the end portions together to fix the support pillow in a desired shape.

Abstract: A support pillow includes a flexible outer sleeve and a deformable inner cushion positioned wholly inside the outer sleeve. Both the outer sleeve and inner cushion are elongate. The outer sleeve is longer than the inner cushion and defines a pair of free end portions extending beyond the inner cushion. The inner cushion is moveable inside the outer sleeve such that the length of each of the free end portions is adjustable. A gripping device can be moved along each end portion to close the outer sleeve around the inner cushion and fix the length of the free end portion extending beyond the inner cushion. The free end portions extend far enough to enable a user to connect the end portions together to fix the support pillow in a desired shape.

Abstract: The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

Abstract: A Entertainment Concept Evaluation is achieved through the use of a Decision Matrix Method. The decision process is a critical tool for aggregating entertainment content on the Internet as well as the monetization of chosen concepts.

Abstract: The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

Abstract: The invention provides compounds of formula (I) and formula (IV) (M)-(L)-(M) (I) [(M)-(L4)]t-G (VI) wherein M, L, L4, G and t are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

Abstract: The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE 4 mediated disease state.

Abstract: The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE 4 mediated disease state.

Abstract: A Entertainment Concept Evaluation is achieved through the use of a Decision Matrix Method. The decision process is a critical tool for aggregating entertainment content on the Internet as well as the monetization of chosen concepts.

Abstract: The present invention provides a compound of a formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.

Abstract: The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed.

Abstract: The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them.

Abstract: The use of compounds of formula (I) wherein X, A, B, D, R1 and R2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

Abstract: The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.

Abstract: The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.