Publication number: 20070088078
Abstract: The present invention provides methods for management fat accumulation in an adipocyte using compositions comprising a polymethoxylated flavone fraction of at least one of 5,6,7,3?,4?-pentamethoxyflavone (sinensetin); 5,6,7,8,3?,4?-hexamethoxyflavone (nobiletin); 5,6,7,8,4?-pentamethoxyflavone (tangeretin); 5-hydroxy-6,7,8,3?,4?-pentamethoxyflavone (auranetin); 5-hydroxy-7,8,3?,4?-tetramethoxyflavone; 5,7-dihydroxy-6,8,3?,4?-tetramethoxyflavone; 5,7,8,3?,4?-pentamethoxyflavone; 5,7,8,4?-tetramethoxyflavone; 3,5,6,7,8,3?,4?-heptamethoxyflavone; 5-hydroxy-3,6,7,8,3?,4?-hexamethoxyflavone; 5-hydroxy-6,7,8,4?-tetramethoxyflavone; 5,6,7,4?-tetramethoxyflavone; 7-hydroxy-3,5,6,8,3?,4?-hexamethoxyflavone; or 7-hydroxy-3,5,6,3?,4?-pentamethoxyflavone. In certain embodiments, methods for preventing rebound weight gain in a subject who has experienced weight loss are provided.
Type:
Application
Filed:
August 22, 2006
Publication date:
April 19, 2007
Inventors:
Slavik Dushenkov, David Evans, Kitty Evans