Patents by Inventor Slavko Rast

Slavko Rast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF
    Publication number: 20260184711
    Abstract: The present disclosure provides compounds having activity as inhibitors of the G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic, and colorectal cancer. In particular, the disclosure provides compounds of Formula (II) and pharmaceutically acceptable salts thereof, wherein the substituents are as described.
    Type: Application
    Filed: October 5, 2023
    Publication date: July 2, 2026
    Applicant: AMGEN INC.
    Inventors: BRIAN A. LANMAN, ADILI ALAFATE, ABHISEK BANERJEE, EMIL GLIBSTRUP, IMELDA HOT, DAVID HUANG, BIRGITTE W. HUSEMOEN, MATTHEW R. KALLER, PATRICIA LOPEZ, VU VAN MA, FRANCESCO MANONI, SLAVKO RAST, NURIA A. TAMAYO, HUI-LING WANG, JINGJING XIE, WENHAN ZHANG
  • COMPOUNDS AS MODULATORS OF STAT6 AND USES THEREOF
    Publication number: 20260166047
    Abstract: Disclosed herein are compounds useful for the inhibition of STAT6. The compounds have a general Formula (I) or (II) or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) and (II) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, diseases/disorders related to the activity of STAT6, such as an allergic disease or an inflammatory disease, including but not limited to atopic dermatitis or bronchial asthma. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I) and (II).
    Type: Application
    Filed: December 16, 2025
    Publication date: June 18, 2026
    Applicant: AMGEN INC.
    Inventors: Liping H. PETTUS, Ana Sydelle BULGER, John Charles STELLWAGEN, Fabien EMMETIERE, Thomas FLAGSTAD, Emil GLIBSTRUP, Jeffrey JACKSON, Qingyian LIU, Quentin TERCENIO, Primali Vasundera NAVARATNE, Adriano BAUER, Slavko RAST, Andrew SMALIGO, Yujia TAO, Zhichen WU, Ningxin XU, John Gordon ALLEN, Dora TOLEDO WARSHAVIAK, Mona SHARAFI, Jason YU, Garrick Paul SMITH, Loris MORETTI, Visnja POLJAK, Adili ALAFATE, Matthew John COOK, Imelda Hot, David Huang, Jose Miguel MEDINA, Milauni Mehta UNDURTY, Cesar Nicolas PRIETO KULLMER, Hui-Ling WANG, Jingjing XIE, Nuria A. TAMAYO, Alexander James Pickrell, Minghao Wang, Wenhan Zhang
  • HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF
    Publication number: 20260132143
    Abstract: The present disclosure provides compounds having activity as inhibitors of the G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic, and colorectal cancer. In particular, the disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the substituents arm as described.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 14, 2026
    Applicant: AMGEN INC.
    Inventors: BRIAN A. LANMAN, SHON BOOKER, JOHN R. BUTLER, EMIL GLIBSTRUP, DAVID HUANG, BIRGITTE W. HUSEMOEN, MATTHEW R. KALLER, TODD J. KOHN, SEBASTIAN LETH-PETERSEN, PATRICIA LOPEZ, QINGYIAN LIU, VU VAN MA, FRANCESCO MANONI, JORGE PEIRO CADAHIA, ALEXANDER J. PICKRELL, SLAVKO RAST, NURIA A. TAMAYO, HUI-LING WANG, WENHAN ZHANG, KAI ZHU, ABHISEK BANERJEE
  • COMPOUNDS ACTIVE TOWARDS BROMODOMAINS
    Publication number: 20250382308
    Abstract: Disclosed are compounds of formula (I) which modulate bromodomains, pharmaceutical compositions containing said compounds and use of said compounds in therapy.
    Type: Application
    Filed: April 19, 2023
    Publication date: December 18, 2025
    Inventors: Garrick Paul SMITH, Slavko RAST, Luigi Piero STASI, Jorge PEIRO CADAHIA, Visnja POLJAK
  • Novel compounds
    Publication number: 20100190764
    Abstract: This invention relates to novel Spiro cyclopentane derivatives of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.
    Type: Application
    Filed: July 24, 2008
    Publication date: July 29, 2010
    Inventors: Emiliano Castiglioni, Romano Di Fabio, Massimo Gianotti, Milan Mesic, Francesca Pavone, Slavko Rast, Luigi Piero Stasi