Patents by Inventor Slawomir Makowiec

Slawomir Makowiec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of [1-hydroxy-2-(1-imidazol-1-yl)- ethylidene]bisphosphonic acid
    Patent number: 8524912
    Abstract: A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
    Type: Grant
    Filed: October 17, 2009
    Date of Patent: September 3, 2013
    Assignee: Zaklady Farmaceutyczne Polpharma SA
    Inventors: Leszek Dembkowski, Mariusz Krzyzanowski, Robert Rynkiewicz, Roman Szramka, Zdzislaw Roznerski, Daniel Zyla, Janusz Rachon, Slawomir Makowiec
  • Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof
    Patent number: 8450488
    Abstract: The invention relates to a novel process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid and hemipentahydrate monosodium salt thereof comprising (a) reacting an aqueous solution of 3-pyridyl acetic acid hydrochloride with phosphorus trichloride; (b) removing unreacted phosphorus trichloride; (c) adding water and hydrolyzing; (d) isolating crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid; (e) suspending said crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid in water; (f) adding sodium hydroxide, filtering off, and washing; and (g) drying obtained hemipentahydrate monosodium salt of 1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: May 28, 2013
    Assignee: Zaklady Farmaceutyczne Polpharma S.A.
    Inventors: Leszek Dembkowski, Robert Rynkiewicz, Janusz Rachoń, Slawomir Makowiec, Witold Przychodzeń, Dariusz Witt
  • PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE] BISPHOSPHONIC ACID
    Publication number: 20120116092
    Abstract: A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
    Type: Application
    Filed: October 17, 2009
    Publication date: May 10, 2012
    Applicants: POLITECHNIKA GDANSKA, ZAKLADY FARMACEUTYCZNE POLPHARMA S.A
    Inventors: Leszek Dembkowski, Mariusz Krzyzanowski, Robert Rynkiewicz, Roman Szramka, Zdzislaw Roznerski, Daniel Zyla, Janusz Rachon, Slawomir Makowiec
  • PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE] BISPHOSPHONIC ACID AND HEMIPENTAHYDRATE MONOSODIUM SALT THEREOF
    Publication number: 20090281320
    Abstract: The invention relates to a novel process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof comprising (a) reacting an aqueous solution of 3-pyridyl acetic acid hydrochloride with phosphorus trichloride; (b) removing unreacted phosphorus trichloride; (c) adding water and hydrolyzing; (d) isolating crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid; (e) suspending said crystalline [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid in water; (f) adding sodium hydroxide, filtering off, and washing; and (g) drying obtained hemipentahydrate monosodium salt of 1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid.
    Type: Application
    Filed: December 28, 2005
    Publication date: November 12, 2009
    Applicants: ZAKLADY FARMACEUTYCZNE POLPHARMA SA, POLITECHNIKA GDANSKA
    Inventors: Leszek Dembkowski, Robert Rynkiewicz, Janusz Rachon, Slawomir Makowiec, Witold Przychodzen, Dariusz Witt