Patents by Inventor Slawomir Szymanski

Slawomir Szymanski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multimeric piperidine derivatives
    Publication number: 20200308144
    Abstract: The technology relates in part to compounds that bind to multimeric ligand binding regions, referred to herein as “multimeric compounds.” In certain examples, the multimeric compounds provided herein bind to and multimerize polypeptides that bind to rimiducid, such as for example, chimeric polypeptides that comprise FKBP12 polypeptide variant regions. Multimeric compounds provided include those having a structure of Formula I. Where A, Z, Y, Z? and A? moieties are described herein.
    Type: Application
    Filed: December 19, 2018
    Publication date: October 1, 2020
    Inventors: Steven Toler, Slawomir Szymanski
  • Inhibitors of glycolysis useful in the treatment of brain tumors
    Patent number: 9149489
    Abstract: Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 6, 2015
    Assignee: Board of Regents, University of Texas System
    Inventors: Waldeman Priebe, Charles Conrad, Timothy Madden, Izabela Fokt, Slawomir Szymanski, Leposava Antonovic
  • Compounds for treatment of cell proliferative diseases
    Patent number: 9096499
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: August 4, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • ORALLY BIOAVAILABLE CAFFEIC ACID RELATED ANTICANCER DRUGS
    Publication number: 20150094343
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: June 4, 2014
    Publication date: April 2, 2015
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Waldemar PRIEBE, Izabela FOKT, Slawomir SZYMANSKI, Timothy MADDEN, Jeffrey MYERS, Charles CONRAD
  • COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES
    Publication number: 20140329901
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: January 3, 2014
    Publication date: November 6, 2014
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Waldemar PRIEBE, Nicholas DONATO, Moshe TALPAZ, Slawomir SZYMANSKI, Izabela FOKT, Alexander LEVITZKI
  • Orally bioavailable caffeic acid related anticancer drugs
    Patent number: 8779151
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: July 15, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Waldemar Priebe, Izabela Fokt, Slawomir Szymanski, Timothy Madden, Jeffrey Myers, Charles Conrad
  • Compounds for treatment of cell proliferative diseases
    Patent number: 8648102
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: February 11, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • Iodo-hexose compounds useful to treat cancer
    Patent number: 8299033
    Abstract: Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: October 30, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Slawomir Szymanski, Izabela Fokt, Charles Conrad, Timothy Madden
  • COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES
    Publication number: 20120214850
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: January 13, 2012
    Publication date: August 23, 2012
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • Compounds for treatment of cell proliferative diseases
    Patent number: 8119827
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: February 21, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES
    Publication number: 20110021805
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: June 28, 2010
    Publication date: January 27, 2011
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • Inhibitors of Glycolysis Useful In the Treatment of Brain Tumors
    Publication number: 20110003758
    Abstract: Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.
    Type: Application
    Filed: March 2, 2009
    Publication date: January 6, 2011
    Inventors: Waldemar Priebe, Charles Conrad, Timothy Madden, Izabela Fokt, Slawomir Szymanski, Leposava Antonovic
  • Compounds for treatment of cell proliferative diseases
    Patent number: 7745468
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: June 29, 2010
    Assignee: Board of Regents, University of Texas Systems The
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
  • Iodo-Hexose Compounds Useful to Treat Cancer
    Publication number: 20100152121
    Abstract: Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.
    Type: Application
    Filed: October 19, 2009
    Publication date: June 17, 2010
    Inventors: Waldemar Priebe, Slawomir Szymanski, Izabela Fokt, Charles Conrad, Timothy Madden
  • Small Molecule Inhibitors for Immune Modulation
    Publication number: 20100144802
    Abstract: Methods of treating immunosuppression by administering a therapeutic amount of a tryphostin compound of the formula:
    Type: Application
    Filed: March 28, 2008
    Publication date: June 10, 2010
    Inventors: Amy B. Heimberger, Waldemar Priebe, Izabela Fokt, Slawomir Szymanski, Sakina Hussain, Ling Y. Kong
  • Hexose Compounds to Treat Cancer
    Publication number: 20100130434
    Abstract: Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a hexose compound to a subject in need thereof The subject invention includes methods of treating brain and pancreatic cancer comprising the administration of a therapeutically effective amount of a mannose compound to a subject in need thereof The subject invention further includes methods of treating the proliferation of tumors comprising the administration of a therapeutically effective amount of 2-FM to a subject in need thereof.
    Type: Application
    Filed: February 26, 2007
    Publication date: May 27, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Waldemar Priebe, Izabela Fokt, Charles Conrad, Sigmund Hsu, Slawomir Szymanski, Theodore Lampidis
  • Orally Bioavailable Caffeic Acid Related Anticancer Drugs
    Publication number: 20070232668
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: April 2, 2007
    Publication date: October 4, 2007
    Inventors: Waldemar Priebe, Izabela Fokt, Slawomir Szymanski, Timothy Madden, Jeffrey Myers, Charles Conrad
  • Compounds for treatment of cell proliferative diseases
    Publication number: 20050277680
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
    Type: Application
    Filed: December 13, 2004
    Publication date: December 15, 2005
    Inventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki