Patents by Inventor Smita NAHAR

Smita NAHAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2?/3?/5?-(R/S)-serinyl functionalized oligonucleotides
    Patent number: 9920319
    Abstract: The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2? of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2?-O-[R/S-(2-amino-3-methoxy)propyl] nucleic acids with both ?3- and 5?-ends capped with two units of abasic serine have antisense activity against the miRNA.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 20, 2018
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Vaijayanti Anil Kumar, Venubabu Kotikam, Souvik Maiti, Smita Nahar
  • Novel 2'/3'/5'-(R/S)-Serinyl Functionalized Oligonucleotides
    Publication number: 20170044527
    Abstract: The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2? of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2?-O-[R/S-(2-amino-3-methoxy)propyl] nucleic acids with both ?3- and 5?-ends capped with two units of abasic serine have antisense activity against the miRNA.
    Type: Application
    Filed: May 2, 2014
    Publication date: February 16, 2017
    Inventors: Vaijayanti Anil KUMAR, Venubabu KOTIKAM, Souvik MAITI, Smita NAHAR