Abstract: The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

Abstract: The present disclosure provides for a wrist arthroplasty system and method that enable an expedient surgical procedure, maintain wrist motion, and reduce the likelihood of implant loosening. The system includes a capitate implant, a radial implant, and a resection instrument. The capitate implant includes a convex head formed to interface with a concave socket of the radial implant. The capitate implant includes a single stem formed to be secured within a patient's capitate bone. The radial implant includes lips formed to increase wrist joint motion and to help prevent dislocation of the capitate implant from the radial implant. The resection instrument may be used in combination as a measurement tool for determining the proper implant size, a guide for properly positioning the implants, and a trial tool for testing trial implant components before securing the final radial and capitate implants.

Abstract: An orthodontic mould to be applied to one or more of a patient's teeth, the mould having: at least one cavity configured to be positioned adjacent a respective tooth of the patient, with the at least one cavity to receive a settable material to provide a projection, the projection to be fixed to a respective one of the teeth; and a rod or stint mounted in the mould and extending from the at least one cavity so as to be secured to the projection when the settable material is set.

Abstract: Systems and methods for producing dicyclopentadiene from cyclopentadiene using reactive jet mixing are disclosed. A C5 hydrocarbon mixture that comprises cyclopentadiene (C5H6) is injected as a jet stream into C5 hydrocarbon liquid in a reactor tank. Under appropriate reaction conditions, cyclopentadiene is dimerized to form dicyclopentadiene.

Abstract: Tag data is created from in-band data in a media content item by a remote location while the media content item is being broadcasted by a content provider and received by the remote location. The tag data identifies locations in the media content item which enables media devices to accurately jump to particular locations in the media content item based on the tag data.

Abstract: Described are systems and methods directed to generation of a personalized three-dimensional (“3D”) body model of a body, such as a human body, based on two-dimensional (“2D”) images of that body and the generation and presentation of predicted personalized 3D body models of the body when one or more body measurements (e.g., body fat, body weight, muscle mass) are changed. For example, a user may provide a target body measurement value and the implementations will generate one or more predicted personalized 3D body models representative of a predicted appearance of the body with the target body measurement value.

Abstract: A method and system for effecting changes on a mobile device. The method includes determining a physical location of a point of interest. The method includes automatically generating a geofence proximate to the point of interest based on the determined physical location of the point of interest. The method includes detecting when the mobile device enters the geofence. The method includes tracking a current velocity of a mobile device. The method also includes effecting a change on the mobile device based on the current velocity of the mobile device within the geofence.

Abstract: A glass article including, on an oxide basis, from 60 mol % to 74 mol % SiO2, from 7 mol % to 18 mol % Al2O3, from 3 mol % to 16 mol % B2O3, from 0 mol % to 6 mol % Na2O, from 0 mol % to 5 mol % P2O5, from 5 mol % to 11 mol % Li2O, less than or equal to 0.2 mol % SnO2, and from 0.5 mol % to 6.5 mol % divalent cation oxides. The glass article has a molar ratio of Al2O3:(R2O+RO) greater than or equal to 0.9, where R2O is a sum of alkali metal oxides in mol % and RO is a sum of divalent cation oxides in mol %.

Abstract: Response parameters for a population of RFID tags present in an inventory space are determined by (a) continuously scanning the inventory space to interrogate the population of RFID tags and receiving responses from RFID tags within the population; (b) after multiple responses have been received from a specific RFID tag, determining response times for the specific RFID tag corresponding to time periods between sequential ones of the multiple responses from the specific RFID tag, (c) calculating a maximum acceptable response time based at least in part on the response times determined in step (b); and (c) recording a response interval data set including one or more of the response times determined in step (b) and the maximum acceptable response time calculated in step (c).

Abstract: A system validates the establishment and/or continuation of a connection between two applications over a network using a two-stage process: (1) a local security agent executing on the same source system as the source application validates the connection against a set of policies stored locally on the source system; and (2) a local security agent executing on the same destination system as the destination application validates the connection against a set of policies stored locally on the destination system. The connection is allowed or blocked depending on the outcome of the two-stage validation. Before the validation process, a policy enforcement engine distributes copies of a trusted public certificate to the source and destination local security agents, which extend their local copies of the certificate to enable them to enforce policies without the use of a backend system.

Abstract: A method for generating and using multi-view masters involves selecting a master in a design environment. A widget is added to the master. A first view is selected for the master. A first widget characterization of the widget is received. The first widget characterization is associated with the first view of the master. A second view of the master is selected. A second widget characterization of the widget is received. The second widget characterization is associated with the second view of the master. An instance of the master is placed in a containing context. A first instance view selection is received, the first instance view selecting the first view of the master for the first instance of the master. The first instance of the master is displayed within the containing context, the widget being displayed in accordance with the first widget characterization associated with the first view of the master.

Abstract: The present invention relates to methods of fabrication of hollow shells/spheres/particles, core-shell particles and composite materials made from these particles.

Abstract: A server computing device may be configured to register a parcel with a component (e.g., another server, etc.) in a dynamic spectrum arbitrage (DSA) system, generate a telecom resource right unit or information structure, and use the generated telecom resource right unit or information structure (e.g., in conjunction with components in the DSA system) to allocate the identified telecommunication resource for access and use by wireless devices that subscribe to a telecommunication network registered with the DSA system.

Abstract: A system and method are described that can help gas stations detect attempted thefts of gas or when there is leakage from a fuel tank or pump. The fuel pump can comprise a payment processing system or is fuel sensor to detect the amount of fuel pumped. The large fuel tank that supplies the fuel pumps can comprise a fuel level sensor to detect how much fuel is being used. The fuel pumps and tanks can send their data to the kiosk or some other location for analysis. If more fuel is being lost from the fuel tank than is being paid for at the pumps, then a theft may be occurring, or there may be fault machinery or leaks.

Abstract: An automatic animal processing device for automatically processing a domestic animal from its stall the animal while restraining the animal and without impeding passage in the aisle. The animal processing device, while operating, allows a person to walk-by the system with minimal constraints. The animal processing device may be a milking machine may be a milking machine having a milking head assembly and a cleaning system. The animal processing device may be mounted on a movable platform, such that the processing device may be automatically moved from one stall to the next. For installations in which the processing device is installed on tracks in the middle of two rows of animals, the processing device may be rotatable on its movable platform, such that it may process the animals of both sides of the aisle.

Abstract: Aspects of the present disclosure involve systems for providing multiple egress routes from a telecommunications network for a client of the network. In general, the system provides for a client of the network to receive intended packets of information through multiple connections to the network such that load balancing and failover services for traffic to the customer are provided. The process and system allows for telecommunications network to utilize a common next-hop value of announced border gateway protocol (BGP) routes to advertise multiple routes to reach a destination customer network or address. By utilizing a common next-hop value in the announced BGP information, the devices of the network may load balance communication packets to the destination customer or address among the multiple egress locations from the network, as well as providing fast failover to alternate routes when a failure at the network or customer occurs.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate and manage secure shipment of a package. An example shipment coordination apparatus includes an address generator and a verification engine. The example apparatus includes a shipping group coordinator to generate a group including a sender and a receiver based on a) a first digital address associated with the sender, b) a second digital address associated with the receiver, and c) at least one encryption key associated with at least one of the first digital address or the second digital address, the shipping group coordinator to initiate delivery instruction and manage receipt confirmation of a package at a second physical address corresponding to the second digital address based on verification of a token identifying the receiver and to provide messaging between the sender and the receiver in the group using a group encryption key to keep messages private in the group.

Abstract: A plenum assembly configured for electrophysiology assays, such as patch clamp techniques, includes one or more ground electrode assemblies. The ground electrode assemblies are individually removable from a plenum base of the plenum assembly in a non-destructive manner, and may be reinstalled in the plenum base in a manner that reestablishes electrical contact with ground circuitry without requiring soldering or other additional steps. A rejuvenating apparatus is provided for rejuvenating one or more ground electrode assemblies removed from the plenum base.

Abstract: In one aspect there is provided a ram block inner seal assembly comprising a core member having a top face, a bottom face, a front face, a rear face, and two side faces. A connector portion connects the top and bottom faces. A peripheral member surrounds the front, rear and side faces. The core member further comprises a peripheral groove on at least the front and side faces, the peripheral groove having a cross-sectional profile. The peripheral member further comprises an energizing section that has a cross-sectional profile which substantially matches the cross-sectional profile of the peripheral groove.