Abstract: The specification relates to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for use in the treatment of cancer, wherein the EGFR TKI is administered in combination with a Smac mimetic.

Abstract: An apparatus may include a capacitance-based trackpad, a tracking driver in communication with the capacitance-based trackpad, a key driver in communication with the capacitance-based trackpad, a processor, and a memory having programmed instructions that, when executed, may cause the processor to modify the raw track inputs to associate a non-confidence indicator with at least one raw track input from the track inputs to form processed track inputs, send the processed track inputs to the tracking driver, and send the processed track inputs to the key driver. The tracking driver may be configured to receive raw track inputs from the capacitive-based trackpad and the key driver may be configured to receive raw key inputs from the capacitance-based trackpad.

Abstract: An iron containing bioreactor for treating explosive compounds and other organics in contaminated surface water is disclosed. The bioreactor can be located either on-ground or in-ground at a location across which contaminated surface water flows. In one configuration the reactor is made up of (i) indigenous microbes, (ii) acetate, (iii) a low density iron-containing bed, and contains anaerobic zones in at least one portion of the flowpath. The reactor reduces the concentration of explosive compounds to below 10 ppb and also maintains this explosive compound reduction level for a period of at least one year without replenishing the microbes or iron.

Abstract: An inventory of computer resources requiring backup data protection including an estimate of future growth of storage resources along with a set of data retention policies, rules, and outcomes in conformance with business requirements, is created. An architecture for initial ingest of protected data and a backup execution approach is created, based on the resource inventory, a sizing and assumptions of resources and data, and the set of data retention policies, rules, and outcomes. An initial ingest copies the protected data to the backup storage. The initial ingest architecture is transformed to a steady-state ingest phase, by incrementally adjusting the resources based on progress of the initial ingest. Responsive to completing the initial ingest of protected data, a steady-state backup ingest is performed. A validity of the sizing and assumptions of architecture resources is determined and an adjustment to the resources is performed based on the validity determination.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: A system and method for determining location information with respect to a portable device and an object. The system and method may be based on UWB communications, and more particularly with respect to a first path power determined with respect the UWB communications. In one embodiment, a differential first path power may be determined based on first and second first path power values obtained respectively by first and second devices via UWB communications with the portable device.

Abstract: An exoskeleton system, the exoskeleton system comprising one or more actuator units that include a fluidic actuator, one or more sensors and an exoskeleton device. The exoskeleton device includes a fluidic system, and a processor and memory, the memory storing instructions, that when executed by the processor, are configured to control the exoskeleton system to introduce fluid to the fluidic actuator of the one or more actuator units to cause actuation of the fluidic actuator of the one or more actuator units. The exoskeleton system may be configured to operate in, on or around a body of water and can be water and/or corrosion resistant.

Abstract: A fluid cooled mold plate is disclosed. The fluid cooled mold plate has a front side, a rear side, and a perimeter that extends between its front and rear sides. A cooling chamber is formed within the mold plate. The cooling chamber has a front wall, a rear wall, and a perimeter wall that extends between the front and rear walls. An inlet fluid duct extends from a first side of the mold plate perimeter to a first end of the cooling chamber and an outlet fluid duct extends from a second side of the mold plate perimeter to a second end of the cooling chamber. The cooling chamber is occupied by a turbulence generating dispersion mesh that is secured between the front and rear walls the cooling chamber.

Abstract: The invention includes a method including the steps of obtaining a plurality of images, each of the images in the plurality having at least one corresponding region, generating a merged image, the merged image also having the corresponding region. The step of generating includes selecting an image source from the plurality of images to source image data for the corresponding region in the merged image by comparing attributes of the corresponding regions of the plurality of images to identify the image source having preferred attributes.

Abstract: A system for increasing the rate of claim approval for specialty drugs is provided. The system monitors the approval and disapproval rates for claims related to specialty medications for multiple providers (e.g., pharmacies) due to missing or incomplete prior authorization requests. When the approval rate for a particular drug for a provider falls below a threshold value due to incomplete or missing prior authorization requests, the system provides the manufacturer of the drug with training on how to complete prior authorization requests for the drug. For example, the provider may be invited to an online course, or instructors may offer to visit the provider to provide additional training. The drug manufacturers may reimburse the claim processing system for identifying those providers who could benefit from the training.

Abstract: A gaming system and method that provides an extra award feature in a gaming environment, wherein the extra award feature provides an easier way than known methods for providing non-linear adjustments to the average expected return for the player for a play of a game without changing or reconstructing the underlying components of the game or any related game. The extra award feature provides for these non-linear adjustments to the average expected return to the player that can be based in part on wager level increases by the player. The extra award feature can include a determination of whether to provide the player a first extra award, and in certain instances, a determination of whether to provide the player a second extra award based in part on an escrow pool.

Abstract: In one aspect, a playback device is provided that is configured to identify a trigger event indicating a request to associate the playback device with another playback device. Based on identifying the trigger event, the playback device is configured to create a first sound code based on a first sound specimen detected by the playback device. After identifying the trigger event, the playback device is configured to receive from the other playback device a sound object and based on receiving the sound object, identify a second sound code. The playback device is also configured to, based on the first sound code and the second sound code, determine that it and the other playback device have a spatial relationship. Based on that determination, the playback device is configured to cause it and the other playback device to be associated in accordance with the indicated request.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: The technology relates to providing an enhanced user experience for riders in autonomous vehicles. Two or more displays may be arranged at different locations within a vehicle to provide notifications, alerts and control options. Information may be dynamically and automatically switched between these displays, as well as a rider's own personal communication device(s). What information to present on each screen can depend on factors including how many riders are in the vehicle, their seating within the vehicle, how their attention is focused and/or display location and size. Certain information may be mirrored or otherwise duplicated among multiple screens while other information can be presented asymmetrically on different screens. Presented information may include a “monologue” from the vehicle explaining why a driving action is taken or not taken, alerts about important conditions, buttons to control certain functionality of the vehicle, or other information that may be of interest to the rider.

Abstract: A clipping system includes a cap, a clip and a control member. The cap includes a channel extending therethrough. A proximal portion of the cap is mounted over the endoscope such that a distal portion of the cap extends distally past a distal end of an endoscope. The distal portion of the channel includes opposing surfaces therealong defining a tapered portion tapering from the distal end of the cap toward a proximal end. The clip is mounted within the cap. The clip includes jaws movably connected via hinges. At least one of the hinges is biased to move the jaws away from one another. The clip is movable relative to the cap between open and closed configurations. The control member longitudinally movable relative to the cap to move the clip between the open and closed configurations.

Abstract: The copolymer includes divalent units represented by formula —[CF2—CF2]—, at least one divalent unit represented by formula (I): and at least one divalent unit independently represented by formula (II): A is —N(RFa)2 or a is non-aromatic, 5- to 8-membered, perfluorinated ring comprising one or two nitrogen atoms in the ring and optionally comprising at least one oxygen atom in the ring, each RFa is independently linear or branched perfluoroalkyl having 1 to 8 carbon atoms and optionally interrupted by at least one catenated O or N atom, each Y is independently —H or —F, with the proviso that one Y may be —CF3, h is 0, 1, or 2, each i is independently 2 to 8, and j is 0, 1, or 2. A catalyst ink and polymer electrolyte membrane including the copolymer are also provided.

Abstract: A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

Abstract: A configurable-width industrial weighing scale configured to hang directly from one of multiple engine-powered lifting machines and/or to couple to a quick-attach plate or other attachment means of an engine-powered lifting machine and configured to directly support a lifting element and/or couple to a quick-attach plate or other attachment means of a lifting element. A weighing element includes front and rear plates in parallel with one another and a weighing assembly therebetween. The weighing assembly may include a strain gauge-based load cell, a shock absorber, a mechanical preload adjustment to control a vertical difference between the front and rear plates, a mechanical linearity control to adjust an angle of the weighing assembly, a carriage alignment bolt to compensate for an uneven surface of a lifting carriage of the engine-powered lifting machine, and/or a mechanical adjustment to compensate for a distance between the front plate and a load.

Abstract: A multi-band antenna has a feed point, a grounding location, a first portion for low band operation, a second portion for low band operation, and one or more portions for high band operation. The ground reference of the feed point for the multi-band antenna is connected to a separate object that may provide a base for the multi-band antenna. The feed point of the multi-band antenna may be spaced above the base and have a space between the feed point and a location for the ground point. The low band portion has multiple resonances that are often odd multiples of the lowest resonant response. The portions that resonant most dominantly in the high band often have multiple resonances that are even multiples of the lowest high band resonance. The multi-band antenna has resonances spaced closely enough to appear to be a wide band antenna above the fundamental high band resonance.

Abstract: An adjustable kettlebell system includes a base having a rod extending from the base. A selector is threaded onto the rod. The rod and selector extend through a plurality of weight supports. Each weight support is connected to an underlying weight support with a connector. As the selector is moved along the length of the rod by rotating the rod, the selector causes the connector to disengage with the underlying weight support. The adjustable kettlebell is then removed without the underlying weight support connected to the handle.