Abstract: Aspects of the invention include generating a set of via mesh specifications for a cell within an integrated circuit. Each via mesh specification defines one or more straps on each layer above a first layer, which includes one or more pins that form a pin terminal, to a top layer that connects the cell to a net for interconnection of the cell with one or more other cells, and also one or more vias that interconnect adjacent ones of the layers. Aspects also include verifying whether each via mesh specification is a universally routable via mesh specification guaranteeing that the cell interconnects with other cells through the net while meeting all design rules, and including only the via mesh specifications of the set of via mesh specifications that are universally routable in a library of via mesh specifications. The library is used to finalize and fabricate the integrated circuit.

Abstract: Methods for treating tumors comprising cells overexpressing ErbB2 or ErbB3 are provided, and comprise inhibiting the biologic activity of one or more of ErbB2 and ErbB3 in the cells and inhibiting the expression or the biologic activity of a constituent of a signal pathway connected with ErbB2 or ErbB3 signaling.