Abstract: Medical probes having an inner fluidic path for flowing an internal liquid therein are disclosed, in which at least one internal surface in flow communication with the inner fluidic path is hydrophilic for the reduction of bubble adhesion thereto. In some embodiments, imaging probes are described, in which an internal surface in flow communication with an internal fluidic path, and through which imaging energy propagates, is coated with a hydrophilic layer that has a thickness and/or an acoustic impedance for reducing an impedance mismatch. Various configurations are described, including embodiments in which hydrophobic bubble trapping surface regions are included in addition to the hydrophilic surface regions. In some embodiments, a medical probe may have an inner lumen defined by an inner fluidic conduit, where at least a portion of the inner surface of the inner fluidic conduit is hydrophilic.