Abstract: The antihypoxic drug with verebroprotective and hepatoprotective action contains piracetam and orotic acid or their pharmaceutically tolerable salts in a weight ratio of from 500:1 to 1:2. This combined drug is administered for the treatment of acute and chronic diseases and exogenic intoxications in daily doses respectively from 0.150 to 50 g and from 0.030 to 0.30 g of both components. The synergistic effect of the combination is shown in the antihypoxic action as confirmed by clinical data. The drug can be administered orally or parenterally. The oral therapy comprises tablets, capsules, pills, solutions and emulsions and is applied in slight forms of exogenic intoxications, whereas the parenterally therapy is suitable in case of severe diseases and acute exogenic intoxications leading to complex injuries of the organism.

Abstract: This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H.sub.2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N"]-2(4-methyl-imidazolyl)-methylthio-[ethylguanidine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1.