Abstract: The present invention relates to a method for preparing a single isomer of 1-(1-(2-benzylphenoxy)propan-2-yl)-2-methylpiperidine in high purity.

Abstract: The simulation system for predicting heating and cooling loads of a building comprises the collection unit collecting measurement data of a target building from a BEMS, the identification unit identifying indoor and outdoor temperature, humidity, and insolation measured in the building in real time based on RTS method, the correlation derivation unit deriving a correlation between energy usage based on the BEMS measurement data collected by the collection unit and the cooling and heating loads according to indoor and outdoor temperature, humidity, and insolation identified by the identification unit, the simulation unit predicting a change in cooling and heating loads according to a change in at least one of pieces of measurement data based on the correlation derived from the correlation derivation unit to perform a simulation, and the information provision unit providing a simulation result from the simulation unit in a visible form to a user terminal.

Abstract: The present invention provides a method of modulating T cell receptor (“TCR”) dependant regulation of a signaling factor in a T cell, and a method of modulating the proliferation and/or differentiation of a T cell, which includes administering to the T cell an IBP modulator in an amount effective to modulate the function of IBP. The present invention further provides a method and a kit for identifying a modulator of IBP-Lck interaction, a modulator of IBP-PI(3,4,5)P3 interaction, a modulator of a signaling factor in a T cell. Also provided are compositions containing an IBP modulator.