Abstract: Microneedles comprising surface-modified microspheres which exhibit improved residence time in body and superior sustained-release effect, and are suitable for the treatment of diseases requiring continuous drug administration due, and a method of preparing the same, are disclosed herein. Microneedles comprising surface-modified microspheres containing a drug according to the present invention exhibit improved residence time in the body and an superior sustained-release effects, and are therefore useful for treatment of conditions and diseases requiring continuous drug administration.

Abstract: Microneedles comprising hormone-containing surface-modified microspheres which exhibit improved residence time in the body and superior sustained-release effect, and a method of preparing the same, are disclosed herein. Microneedles including surface-modified microspheres containing a hormone according to the present invention exhibit improved residence time in the body and superior sustained-release effect, and are therefore useful for a transdermal delivery system for delivering a hormone requiring continuous administration.

Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Abstract: The present invention relates to a method for preparing an ionic liquid having a carboxylic acid anion using a microreactor. More specifically, the present invention relates to a method for preparing, with high efficiency, an ionic liquid having a carboxylic acid anion as shown in FIG. 1, by having sodium butanoate, sodium 2-ethylhexanoate, or sodium octanoate undergo a substitution reaction with 1-alkyl-3-methylimidazolium, 1,1-alkylmethylpyrrolidinium, 1,2-dimethyl-3-alkylimidazolium, 1-alkyl-3-methylpyridinium, or tetramethylammonium, each of which being a cation. The ionic liquid prepared according to the present invention has high purity, containing residual halide at less than 10 ppm, and has high electrical conductivity, and therefore is capable of being used as an electrolyte or for a condenser.

Abstract: The present invention relates to a preparation method, which involves synthesizing BMIM/Cl, which is an ionic liquid, from AlCl3 and TiCl4, which are Lewis acids, and which enables the synthesized body to be supported by Al2O3 serving as a support. The preparation method of the present invention uses AlCl3 and TiCl4, which are not used in existing methods, so as to prepare a supported ionic liquid. The preparation method of the present invention uses water as a solvent to efficiently relieve reaction conditions and avoid the risk of heating during the reaction, and thus enables supported ionic-liquid products to be continuously prepared in a stable manner.