Abstract: A medicament having a higher therapeutic effect than that provided by administration of a recombinant antibody against human CC chemokine receptor 4 or an antibody fragment thereof or an agent alone is provided.

Abstract: An operator guidance system includes a detection unit, a control unit, and an operation indicator. The detection unit is disposed in an image forming apparatus to output a combination of detection signals, and includes one or more media sensors, and one or more opening sensors. The one or more media sensors are disposed along a media conveyance path to output a media detection signal. The one or more opening sensors are disposed adjacent to an openable structure to output an opening detection signal. The control unit is connected to the detection unit to determine guidance to be provided to an operator based on the combination of detection signals, and includes a memory and a controller. The operation indicator is connected to the control unit to indicate the identified operation to the operator.

Abstract: A medicament having a higher therapeutic effect than that provided by administration of a recombinant antibody against human CC chemokine receptor 4 or an antibody fragment thereof or an agent alone is provided.

Abstract: A medicament having a higher therapeutic effect than that provided by administration of a recombinant antibody against human CC chemokine receptor 4 or an antibody fragment thereof or an agent alone is provided.

Abstract: An operator guidance system includes a detection unit, a control unit, and an operation indicator. The detection unit is disposed in an image forming apparatus to output a combination of detection signals, and includes one or more media sensors, and one or more opening sensors. The one or more media sensors are disposed along a media conveyance path to output a media detection signal. The one or more opening sensors are disposed adjacent to an openable structure to output an opening detection signal. The control unit is connected to the detection unit to determine guidance to be provided to an operator based on the combination of detection signals, and includes a memory and a controller. The operation indicator is connected to the control unit to indicate the identified operation to the operator.

Abstract: The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.

Abstract: An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same.

Abstract: The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.

Abstract: An image forming apparatus includes an image forming mechanism, a sheet conveyance mechanism, and a sheet detector. The image forming mechanism forms an image and transfers it onto the sheet conveyed by the sheet conveyance mechanism. The sheet detector is arranged upstream from an image transfer region and configured to detect the sheet. The sheet detector includes a light source, a plurality of photoreceptors, and a controller. The plurality of photoreceptors is arranged in line in a main-scanning direction and includes a first photoreceptor group and a second photoreceptor group. The first photoreceptor group changes output voltages when overridden by the side edge of the sheet. The second photoreceptor group includes an opposite end of the plurality of photoreceptors being out of the side edge of the sheet. The controller is configured to adjust a light emission amount in accordance with characteristics of the sheet.

Abstract: The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.

Abstract: An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same.

Abstract: The present invention provides an agent which is effective to a patient who is administered by an agent comprising anti-CD20 antibody as an active ingredient.

Abstract: A sheet detector, a sheet detector mechanism and an image forming apparatus. An image forming apparatus may include an image forming mechanism, a sheet conveyance mechanism, and a sheet detector. The image forming mechanism may form an image and transfer the image onto the sheet conveyed by the sheet conveyance mechanism. The sheet detector may be arranged upstream from an image transfer region and configured to detect the sheet. The sheet detector may include a light source emitting light, a plurality of photoreceptors, and a controller. The plurality of photoreceptors may be arranged in a line in a main-scanning direction and may include a first photoreceptor group and a second photoreceptor group. The first photoreceptor group may change output voltages when overridden by the side edge of the sheet. The second photoreceptor group may include an opposite end of the plurality of photoreceptors being out of the side edge of the sheet.

Abstract: A medicament having a higher therapeutic effect than that provided by administration of a recombinant antibody against human CC chemokine receptor 4 or an antibody fragment thereof or an agent alone is provided.

Abstract: An image forming apparatus includes a sheet feed unit having a sheet feed port, an image forming unit, a sheet position detector, a mode selector, and a memory unit. The sheet feed unit feeds a recording sheet. The image forming unit forms an image on the recording sheet. The sheet position detector detects a sheet edge of the recording sheet. The mode selector selects at least one of the position correction mode and non-correction mode for the sheet feed port. An image forming position on the recording sheet is corrected using position information detected by the sheet position detector when the position correction mode is selected, and the image forming position on the recording sheet is not corrected when the non-correction mode is selected. A memory unit may store a plurality of values of light intensity and threshold value corresponding to different types of recording sheets.

Abstract: An image forming apparatus includes a recording sheet type detection device to automatically detect a type of a recording sheet. A setting device sets an image forming condition by an operator. The image forming condition includes the type of the recording sheet. An image forming device forms a visible image on the recording sheet. A sheet feeding device feeds the recording sheet to the image forming device. A controller controls the image forming apparatus not to form an image on the recording sheet when the image forming condition with regard to the type of the recording sheet set by the operator does not match the type of the recording sheet detected by the recording sheet type detection device.

Abstract: The present invention relates to a monoclonal antibody which specifically reacts with natural MT4-MMP or solubilized MT4-MMP. Also, the present invention provides a monoclonal antibody which specifically and efficiently recognizes a natural MT4-MMP catalytic domain; a human chimeric antibody, a CDR-grafted antibody, a single chain antibody and a disulfide stabilized antibody, comprising the same; and a method for detecting and determining MT4-MMP protein using the antibodies. Furthermore, the present invention provides a diagnostic method, a diagnostic agent and a therapeutic agent for various diseases relating to MP4-MMP such as inflammation and cancer, using the antibodies.

Abstract: An image forming apparatus includes a recording sheet type detection device to automatically detect a type of a recording sheet. A setting device sets an image forming condition by an operator. The image forming condition includes the type of the recording sheet. An image forming device forms a visible image on the recording sheet. A sheet feeding device feeds the recording sheet to the image forming device. A controller controls the image forming apparatus not to form an image on the recording sheet when the image forming condition with regard to the type of the recording sheet set by the operator does not match the type of the recording sheet detected by the recording sheet type detection device.

Abstract: An image forming apparatus includes a recording sheet type detection device to automatically detect a type of a recording sheet. A setting device sets an image forming condition by an operator. The image forming condition includes the type of the recording sheet. An image forming device forms a visible image on the recording sheet. A sheet feeding device feeds the recording sheet to the image forming device. A controller controls the image forming apparatus not to form an image on the recording sheet when the image forming condition with regard to the type of the recording sheet set by the operator does not match the type of the recording sheet detected by the recording sheet type detection device.

Abstract: The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.