Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound having a structure according to Formula I, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound having a structure according to Formula I, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Abstract: The present invention relates to a novel exosome-derived biomarker for diagnosis of Alzheimer's disease, a composition for diagnosis of Alzheimer's disease containing the biomarker, a kit for diagnosis of Alzheimer's disease including the composition, and a method for providing information for diagnosis of Alzheimer's disease using the biomarker, composition, or kit. The biomarker for diagnosis of Alzheimer's disease provided by the present invention can be widely utilized for effective diagnosis of Alzheimer's disease and further for treatment of Alzheimer's disease since not only the diagnostic rate of Alzheimer's disease can be increased but also the accuracy, sensitivity, and specificity can be increased through subdivided diagnosis according to the progression stages (healthy, MCI, and AD) of Alzheimer's disease by using the biomarker.

Abstract: Provided is a multiple biomarker simultaneous analysis apparatus comprising: a cartridge mounting portion 210 in which a cartridge 100 is installed, the cartridge 100 including at least one well and a tip 110, wherein the at least one well includes a sample well 101 into which a sample S containing a detection target material T is injected, and a reaction well 105 accommodating a first binding material 105a, which is specifically bound to the detection target material T and to which a marker R is coupled, and the tip 110 is inserted into the at least one well and a second binding material 111 that is specifically bound to the detection target material T is coupled to one end of the tip 110; a tip coupling portion 220 coupled to the tip 110 and movable on a predetermined movement trajectory while being coupled to the tip 110; an optical unit 230 radiating light toward the tip 110 and receiving light generated from the tip 110 according to light radiation; and a processing unit 240 determining whether the detec

Abstract: The present disclosure relates to a ceramic graphene oxide nanofiltration membrane which is high in mechanical stability while having ion removal ability by alternately stacking GO and PEI on a ceramic nanomembrane by allowing a carboxyl group (—COOH) and an amine group (—NH2) to form a covalent bond in the presence of N-ethyl-N?-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDC), thereby forming an amide group (—CONH), and a method for manufacturing the same.

Abstract: A hot stamping method for simultaneously forming workpieces includes steps of: performing laser welding to which an aluminum filler wire is applied to a welding site between the two or more sheets of blanks, and hot-stamping the two or more sheets of blanks, which are welded in the step of performing the laser welding.

Abstract: Disclosed are a human-derived ferritin monomer fragment and a fusion polypeptide using the same, and more particularly, to a human-derived ferritin of which a portion of a fourth loop and a fifth helix of the ferritin monomer fragment are removed, and a fusion polypeptide in which a polypeptide or a protein is fused to an N-terminus or a C-terminus of the ferritin monomer fragment.

Abstract: A hot stamping method for simultaneously forming workpieces includes steps of: performing laser welding to which an aluminum filler wire is applied to a welding site between the two or more sheets of blanks, and hot-stamping the two or more sheets of blanks, which are welded in the step of performing the laser welding.

Abstract: The present invention relates to: a fusion peptide comprising a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide; and a use thereof and, more specifically, to: a fusion peptide in which a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide are sequentially linked; a composition for preventing or treating thrombotic disorders, containing the same as an active ingredient; a method for treating thrombotic disorders; and a therapeutic use. According to the present invention, CLT-sFt-?Pn DCNC as a novel plasmin-based thrombolytic nanocage has: an effect of targeting a site at which thrombus is present; a low sensitivity to inhibitors present in the circulatory system; pharmacological activity strongly destroying both arterial and venous thrombi; and no side effects of bleeding, and thus can be very useful in developing an agent for preventing or treating thrombotic disorders.

Abstract: The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases.

Abstract: There is provided a sol-gel chip using a porous substrate for entrapping small molecules and a method for screening a small molecule-specific material using the same, and more particularly, a porous substrate sol-gel chip characterized in that a sol-gel composition for entrapping small molecules is spotted on a surface of the porous substrate, a method for manufacturing the porous substrate sol-gel chip for entrapping small molecules, and a method for screening a material specifically binding to the small molecules using the porous substrate sol-gel chip for entrapping small molecules. According to the present invention, the small molecules can be effectively entrapped in the chip and the inflow of aptamers can be maintained as compared with the existing methods and thus aptamers specific to an extensive range of small molecules can be more easily selected.

Abstract: A method of manufacturing tailor welded blanks includes bringing a pair of objects to be welded into contact with each other. The objects are formed of different materials having different thicknesses or strengths. The method further includes adjusting the heat input of a radiated laser beam and dividing the radiated laser beam into a preceding laser beam and a following laser beam in a welding direction using an optical prism. The method further includes forming a welded part by sequentially radiating the preceding laser beam and the following laser beam to the pair of objects to be welded while supplying a filler wire to welded regions of the pair of objects to be welded.

Abstract: The present invention relates to a multiplex microfluidic device for selection of nucleic acid aptamers and a method for high-throughput selection of nucleic acid aptamers using the same, and more particularly to a multiplex microfluidic device (SELEX lap-on-a-chip) that uses an improved multiplex platform in place of the development of an aptamer for a single target and to a method for high throughput selection of aptamers using the same together with high-throughput sequencing. A multiplex microfluidic device according to the present invention can simultaneously detect aptamers for a plurality of targets, and it can greatly increase the screening throughput and greatly shorten the process time compared to conventional multiplex techniques.

Abstract: The present invention relates to a method for screening a sol composition for sol-gel biochips, which is used to immobilize a probe on a surface-untreated substrate, also relates to a sol composition screened by said method and a sol-gel biochip comprising said sol composition immobilized thereon. The sol composition screened by the disclosed method can be mixed with a probe, and the sol mixture can be integrated on 96-well plates, which are widely used in existing bioassays, without surface treatment. Also, the biochip can provide a sensitive and specific good analysis results because this immobilization methods of probe maintain the nature of probes without modification.

Abstract: The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases.

Abstract: The present invention relates to a method for screening a substance inhibiting protein-protein interactions, and more particularly to a method for screening a substance inhibiting protein-protein interactions, the method comprising using a protein chip having immobilized thereon spots comprising a mixture of a sol-gel material and a protein. According to the invention, a protein chip can be easily manufactured in a 96-well plate using a sol-gel material, whereby an inhibitor that inhibits protein-protein interactions can be easily screened from a library of natural substances.

Abstract: Disclosed are a human-derived ferritin monomer fragment and a fusion polypeptide using the same, and more particularly, to a human-derived ferritin of which a portion of a fourth loop and a fifth helix of the ferritin monomer fragment are removed, and a fusion polypeptide in which a polypeptide or a protein is fused to an N-terminus or a C-terminus of the ferritin monomer fragment.

Abstract: A method of manufacturing tailor welded blanks may be capable of improving a quality of a welded portion and shortening a manufacturing time when a tailor welded blank is manufactured using a coated steel plate. The method of manufacturing tailor welded blanks includes welding one or more pairs of different coated steel plates having different thicknesses or strengths with laser using a filler wire.

Abstract: The present invention relates to a method for screening a sol composition for sol-gel biochips, which is used to immobilize a probe on a surface-untreated substrate, also relates to a sol composition screened by said method and a sol-gel biochip comprising said sol composition immobilized thereon. The sol composition screened by the disclosed method can be mixed with a probe, and the sol mixture can be integrated on 96-well plates, which are widely used in existing bioassays, without surface treatment. Also, the biochip can provide a sensitive and specific good analysis results because this immobilization methods of probe maintain the nature of probes without modification.

Abstract: The present invention relates to a method for screening a sol composition for sol-gel biochips, which is used to immobilize a probe on a surface-untreated substrate, also relates to a sol composition screened by said method and a sol-gel biochip comprising said sol composition immobilized thereon. The sol composition screened by the disclosed method can be mixed with a probe, and the sol mixture can be integrated on 96-well plates, which are widely used in existing bioassays, without surface treatment. Also, the biochip can provide a sensitive and specific good analysis results because this immobilization methods of probe maintain the nature of probes without modification.