Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.

Abstract: The present invention relates to novel substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.

Abstract: An image acquisition method includes acquiring a first optical signal by emitting a penetrative light beam, which can penetrate a mask layer, to a measurement target mark that is one of marks on a sample, acquiring a second optical signal by emitting a reflective light beam reflecting from the mask layer to the measurement target mark, determining whether the measurement target mark is covered with the mask layer by comparing the first optical signal and the second optical signal, and acquiring a mark image by emitting a first light beam, which penetrates the mask layer, to the measurement target mark when the measurement target mark is covered with the mask layer, and acquiring a mark image by emitting a second light beam different from the first light beam to the measurement target mark when the measurement target mark is not covered with the mask layer.

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: Provided are 5-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.

Abstract: A super frame structure supporting a mesh network, and a beacon scheduling method. The super frame structure and the beacon scheduling method may support a mesh topology in a beacon enabled mode, may have an algorithm that is simple and easily realized via beacon scheduling using a distribution method, and may easily adapt to changes in a network environment.

Abstract: A time synchronization method in a wireless sensor network, a low power routing method using a reservation scheme, and an apparatus for performing the method are provided. The time synchronization method in the wireless sensor network may include: receiving a first synchronization request command packet from a parent node that manages time synchronization for a predetermined synchronization region; receiving, from the parent node, a second synchronization request command packet that has a transmission timestamp value of the first synchronization request command packet; and performing time synchronization for a child node based on a reception time of the first synchronization request command packet, a reception time of the second synchronization request command packet, and the transmission timestamp value of the first synchronization request command packet.

Abstract: There is provided a mesh routing method in beacon-enabled wireless AD-HOC networks that includes: broadcasting, by nodes constituting a wireless AD-HOC network, a beacon message loading neighbor node information on a beacon payload; managing, by a node receiving the broadcasted beacon message, its own neighbor node table by extracting the neighbor node information loaded on the beacon payload; and performing, by a source node attempting to transmit data or commands, mesh routing on the basis of its own neighbor node table.

Abstract: Provided is a method of determining an operation mode of a node in an ad hoc network. The method includes: monitoring a measured amount of residual energy of the node and comparing the measured amount of residual energy of the node with an amount of residual energy theoretically calculated for the node; identifying an amount of information in a queue included in the node; calculating a relay probability of the node by reflecting the identified amount of information in the queue and the result of comparing the measured amount of residual energy of the node with the theoretically calculated amount of residual energy for the node; and determining the operation mode of the node to be one of a relay mode and a transmission mode, based on the calculated relay probability of the node. The method enables nodes to exchange information about their respective amounts of residual energy and analyze the information without using additional resources and processes.

Abstract: Provided is a method and system for managing an identification (ID) of a widely moved sensor node. The method includes recognizing, at a gateway, a node to check an ID of the node, allocating an ID of the gateway as the ID of the node when the ID of the node checked by the gateway is null, sending the ID of the node to a management server when the ID of the node checked by the gateway is not null and is different from the ID of the gateway, and when a new ID is received from the management server, allocating the new ID as the ID of the node.

Abstract: There is provided a mesh routing method in beacon-enabled wireless AD-HOC networks that includes: broadcasting, by nodes constituting a wireless AD-HOC network, a beacon message loading neighbor node information on a beacon payload; managing, by a node receiving the broadcasted beacon message, its own neighbor node table by extracting the neighbor node information loaded on the beacon payload; and performing, by a source node attempting to transmit data or commands, mesh routing on the basis of its own neighbor node table.

Abstract: Provided is a method for operating a network node in a specific cluster of a tree-structured network based on distributed address assignment. In the method, a non-registered node is detected. A routing depth of the network node is determined. When the determined routing depth corresponds to a reference value, a sub cluster using a cluster address is generated, and the detected non-registered node is registered as a child node in the generated sub cluster using an internal address.

Abstract: A time synchronization method in a wireless sensor network, a low power routing method using a reservation scheme, and an apparatus for performing the method are provided. The time synchronization method in the wireless sensor network may include: receiving a first synchronization request command packet from a parent node that manages time synchronization for a predetermined synchronization region; receiving, from the parent node, a second synchronization request command packet that has a transmission timestamp value of the first synchronization request command packet; and performing time synchronization for a child node based on a reception time of the first synchronization request command packet, a reception time of the second synchronization request command packet, and the transmission timestamp value of the first synchronization request command packet.

Abstract: A multi-path routing method is provided a multi-path routing method for selecting appropriate multiple paths when information sensed from a source node is transmitted to a sink node in wireless sensor networks. The source node for transmitting the sensed information first transmits a Hello message to the sink node to identify the existence and position of the sink node. The sink node receives the Hello message and then re-transmits the Hello message with respect to all the received Hello messages. Respective middle nodes accumulate distances between the middle nodes while the Hello message is transmitted to the source node through a reverse path of the Hello message, and all the middle nodes maintain a real distance from the sink node. The source node receiving all the Hello messages can rout a plurality of appropriate paths through Hop-by-hop to the sink node by providing respective weights to an energy remaining amount, an appropriate transmission radius and a real distance from the sink node.

Abstract: Provided is a method of determining an operation mode of a node in an ad hoc network. The method includes: monitoring a measured amount of residual energy of the node and comparing the measured amount of residual energy of the node with an amount of residual energy theoretically calculated for the node; identifying an amount of information in a queue included in the node; calculating a relay probability of the node by reflecting the identified amount of information in the queue and the result of comparing the measured amount of residual energy of the node with the theoretically calculated amount of residual energy for the node; and determining the operation mode of the node to be one of a relay mode and a transmission mode, based on the calculated relay probability of the node. The method enables nodes to exchange information about their respective amounts of residual energy and analyze the information without using additional resources and processes.

Abstract: A super frame structure supporting a mesh network, and a beacon scheduling method. The super frame structure and the beacon scheduling method may support a mesh topology in a beacon enabled mode, may have an algorithm that is simple and easily realized via beacon scheduling using a distribution method, and may easily adapt to changes in a network environment.