Patents by Inventor Soan Cheng

Soan Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS AS INHIBITORS OF PCSK9
    Publication number: 20230122967
    Abstract: Disclosed are a compound of formula (I), wherein the variables are defined in the specification, a pharmaceutical composition containing the same, and a method and a use of the compound or composition in the treatment of a PCSK9-mediated disease such as cardiovascular disease.
    Type: Application
    Filed: January 14, 2021
    Publication date: April 20, 2023
    Inventors: Soan Cheng, Chengzhi Yu, Zuopeng Sun, Chenggang Zhang
  • Gamma-secretase modulators
    Patent number: 9938263
    Abstract: There are provided, inner alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since all of the major AB peptide variants, including the pathogenic AB42 as known in the art, are ultimately generated by gamma-secretase-mediated proteolysis of APP-C99 (i.e., the beta-secretase-mediated cleavage product of the amyloid protein precursor IAPPI), one approach to therapeutic intervention (e.g., intervention in Alzheimer's Disease, AD) relates to lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: April 10, 2018
    Assignees: The General Hospital Corporation, The Regents of the University of California
    Inventors: Rudolph E. Tanzi, Steven L. Wagner, Soan Cheng, William C. Mobley
  • Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms
    Patent number: 9403815
    Abstract: The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)-(C)-(D)??(I) or a pharmaceutically acceptable salt or prodrug thereof and methods for using them.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: August 2, 2016
    Assignees: The Regents of the University of California, The General Hospital Corporation
    Inventors: Steven L. Wagner, Soan Cheng, William C. Mobley, Rudolph E. Tanzi
  • GAMMA-SECRETASE MODULATORS
    Publication number: 20160024073
    Abstract: There are provided, imer alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since all of the major AB peptide variants, including the pathogenic AB42 as known in the art, are ultimately generated by gamma-secretase-mediated proteolysis of APP-C99 (i.e., the beta-secretase-mediated cleavage product of the amyloid protein precursor IAPPI), one approach to therapeutic intervention (e.g., intervention in Alzheimer's Disease, AD) relates to lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Rudolph E. TANZI, Steven L. WAGNER, Soan CHENG, William C. MOBLEY
  • Compounds that modulate intracellular calcium
    Patent number: 8524765
    Abstract: Described herein are compounds and pharmaceutical compositions containing compounds of Formula (I), which modulate the activity of store-operated calcium (SOC) channels: wherein R1, R2 and R4 are defined herein. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 3, 2013
    Assignee: Calcimedica, Inc.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, David P. M. Pleynet, Soan Cheng, Jeffrey P. Whitten
  • COMPOUNDS AND USES THEREOF IN MODULATING LEVELS OF VARIOUS AMYLOID BETA PEPTIDE ALLOFORMS
    Publication number: 20130165416
    Abstract: The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)—(C)-(D)??(I) or a pharmaceutically acceptable salt or prodrug thereof and methods for using them.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 27, 2013
    Inventors: Steven L. Wagner, Soan Cheng, William C. Mobley, Rudolph E. Tanzi
  • COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
    Publication number: 20120289587
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: July 19, 2012
    Publication date: November 15, 2012
    Applicant: CalciMedica, Inc.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, David P.M. Pleynet, Soan Cheng, Jeffrey P. Whitten
  • Compounds that modulate intracellular calcium
    Patent number: 8263641
    Abstract: Described herein are compounds of Formula I and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also describe herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: September 11, 2012
    Assignee: Calcimedica, Inc.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, David P. M. Pleynet, Soan Cheng, Jeffrey P. Whitten
  • ?-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom
    Patent number: 8119680
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: February 21, 2012
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D Comer, Long Mao, Guity P Balow, David Pleynet
  • Compounds and uses thereof in modulating amyloid ?
    Patent number: 8017629
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: September 13, 2011
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • ALPHA-HALOKETONE DERIVATIVES OF IMIDAZOLYL-SUBSTITUTED AROMATIC COMPOUNDS AND COMPOUNDS PREPARED THEREFROM
    Publication number: 20100331551
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Application
    Filed: September 3, 2010
    Publication date: December 30, 2010
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
    Publication number: 20100324032
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 23, 2010
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • ?-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom
    Patent number: 7799808
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: September 21, 2010
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • Compounds and uses thereof in modulating amyloid beta
    Patent number: 7781442
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: August 24, 2010
    Assignee: Neurogenetic Pharmaceuticals, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • Compounds and Uses Thereof in Modulating Amyloid Beta
    Publication number: 20070260058
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Application
    Filed: July 17, 2007
    Publication date: November 8, 2007
    Inventors: Soan Cheng, Daniel Comer, Long Mao, Guity Balow, David Pleynet
  • COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
    Publication number: 20070249833
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 25, 2007
    Inventors: Soan Cheng, Daniel Comer, Long Mao, Guity Balow, David Pleynet
  • Compounds and uses thereof in modulating amyloid beta
    Patent number: 7244739
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: July 17, 2007
    Assignee: Torreypines Therapeutics, Inc.
    Inventors: Soan Cheng, Daniel D. Comer, Long Mao, Guity P. Balow, David Pleynet
  • Organic compounds
    Patent number: 6949669
    Abstract: Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: September 27, 2005
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Gerald Wayne Craig, Martin Eberle, Martin Zeller, Steven Scott Bondy, Daniel Dennis Comer, Soan Cheng, Julie Elizabeth Penzotti, Peter Grootenhuis, Jürg Ehrler
  • Compounds and uses thereof in modulating amyloid beta
    Publication number: 20050070538
    Abstract: Novel compounds, compositions, and kits are provided. Methods of modulating A? levels, and methods of treating a disease associated with aberrant A? levels are also provided.
    Type: Application
    Filed: May 14, 2004
    Publication date: March 31, 2005
    Inventors: Soan Cheng, Daniel Comer, Long Mao, Guity Balow, David Pleynet
  • Organic compounds
    Publication number: 20040049065
    Abstract: Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides.
    Type: Application
    Filed: October 18, 2002
    Publication date: March 11, 2004
    Inventors: Gerald Wayne Craig, Martin Eberle, Martin Zeller, Steven Scott Bondy, Daniel Dennis Comer, Soan Cheng, Julie Elizabeth Penzotti, Peter Grootenhuis, Jurg Ehrler