Patents by Inventor Socrates Herrera

Socrates Herrera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unique DNA and polypeptide sequences based on the circumsporozoite protein of
    Patent number: 7749519
    Abstract: Malaria in humans is caused by infection with Plasmodium species parasites including P. vivax. The biology and immunobilogy of P. vivax is distinct from that of P. falciparum. Provided are unique synthetic polypeptides and DNA molecules which encode them. Each of these molecules correspond to regions of the circumsporozoite protein of P. vivax. Each molecule comprises sequences corresponding to several repeats of the central region of the Pv 210 variant fused to sequences corresponding to several repeats of the central region of the Pv 247 variant. Each molecule additionally comprises sequences corresponding to either the amino terminus, the carboxy terminus, or both the amino and carboxy termini of the PvCSP. Also provided are vaccines comprising these unique sequences and methods of using these vaccines and sequences to prevent and treat Pv malaria.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: July 6, 2010
    Inventors: Kim Lee Sim, Stephen Hoffman, Myriam Arevalo, Socrates Herrera
  • Unique DNA and polypeptide sequences based on the circumsporozoite protein of Plasmodium vivax
    Publication number: 20080057085
    Abstract: Malaria in humans is caused by infection with Plasmodium species parasites including P. vivax. The biology and immunobilogy of P. vivax is distinct from that of P. falciparum. Provided are unique synthetic polypeptides and DNA molecules which encode them. Each of these molecules correspond to regions of the circumsporozoite protein of P. vivax. Each molecule comprises sequences corresponding to several repeats of the central region of the Pv 210 variant fused to sequences corresponding to several repeats of the central region of the Pv 247 variant. Each molecule additionally comprises sequences corresponding to either the amino terminus, the carboxy terminus, or both the amino and carboxy termini of the PvCSP. Also provided are vaccines comprising these unique sequences and methods of using these vaccines and sequences to prevent and treat Pv malaria.
    Type: Application
    Filed: December 11, 2006
    Publication date: March 6, 2008
    Inventors: Kim Sim, Stephen Hoffman, Myriam Arevalo, Socrates Herrera