Patents by Inventor Soeren Kjaerulff
Soeren Kjaerulff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130045485Abstract: Disclosed is a fast and simple method for quantification of nucleic acid of biological cells as 2-step protocol. In the first step cells are treated with an acidic solution containing a non-ionic detergent and a fluorescent DNA specific label. In the second step the sample may be neutralised. Determining of the content of nucleic can be performed by fluorescence microscopy. The method may also be used for obtaining information of cell cycle analysis, ploidy determination, measurements of nucleotide incorporation and assays for proliferation, health, stress level, apoptosis, necrosis, or other state of conditions of cells. The invention also relates to a kit of parts comprising an acidic agent, a detergent, a labelling agent and optionally a neutralization agent.Type: ApplicationFiled: February 10, 2011Publication date: February 21, 2013Applicant: CHEMOMETEC A/SInventors: Søren Kjaerulff, Martin Glensbjerg
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Publication number: 20120309686Abstract: The present invention relates to treatment of rheumatoid arthritis with mammal beta defensins.Type: ApplicationFiled: July 9, 2012Publication date: December 6, 2012Applicant: Novozymes Adenium Biotech A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Publication number: 20120309678Abstract: The present invention relates to treatment of inflammatory bowel diseases with mammal beta defensins.Type: ApplicationFiled: July 9, 2012Publication date: December 6, 2012Applicant: Novozymes Adenium Biotech A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Publication number: 20120252095Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased.Type: ApplicationFiled: May 23, 2012Publication date: October 4, 2012Applicant: NOVOZYMES A/SInventors: Allan Svendsen, Sóeren Kjaerulff, Henrik Bisgaard-Frantzen, Carsten Andersen
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Patent number: 8232242Abstract: The present invention relates to treatment of inflammatory bowel diseases with mammal beta defensins.Type: GrantFiled: July 17, 2009Date of Patent: July 31, 2012Assignee: Novozymes Adenium Biotech A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Patent number: 8232248Abstract: The present invention relates to treatment of rheumatoid arthritis with mammal beta defensins.Type: GrantFiled: July 17, 2009Date of Patent: July 31, 2012Assignee: Novozymes Adenium Biotech A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Publication number: 20120122754Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.Type: ApplicationFiled: January 20, 2012Publication date: May 17, 2012Applicant: NOVOZYMES A/SInventors: Carsten Andersen, Christel Thea Jørgensen, Henrik Bisgård-Frantzen, Allan Svendsen, Søren Kjærulff
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Publication number: 20120045757Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: ApplicationFiled: October 21, 2009Publication date: February 23, 2012Inventors: Søren Kjaerulff, Mette Elena Skindersø, Helle Frobøse Sørensen, Frans Ejner Ravn, Martin Glensbjerg
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Publication number: 20110312012Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).Type: ApplicationFiled: July 13, 2009Publication date: December 22, 2011Applicant: ChemoMetec A/SInventors: Mette Elena Skinderso, Helle Frobøse Sørensen, Søren Kjærulff
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Publication number: 20110312013Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI).Type: ApplicationFiled: July 14, 2009Publication date: December 22, 2011Applicant: CHEMOMETEC A/SInventors: Mette Elena Skindersø, Helle Frobøse Sørensen, Søren Kjærulff
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Publication number: 20110287516Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased.Type: ApplicationFiled: March 2, 2011Publication date: November 24, 2011Applicant: Novozymes A/SInventors: Allan Svendsen, Soeren Kjaerulff, Henrik Bisgaard-Frantzen, Carsten Andersen
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Publication number: 20110251139Abstract: The present invention relates to treatment of inflammatory bowel diseases with mammal beta defensins.Type: ApplicationFiled: June 13, 2011Publication date: October 13, 2011Applicant: NOVOZYMES A/SInventors: TANJA MARIA ROSENKILDE KJAER, THOMAS KRUSE, PER HOLSE MYGIND, KAROLINE SIDELMANN BRINCH, SOEREN KJAERULFF, BIRGITTE ANDERSEN
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Publication number: 20110086132Abstract: A transgenic plant cell expressing a maltogenic amylase (such as Novamyl®) or a beta-amylase; a transgenic plant regenerated from said cell; seeds generated from such plant where said seeds comprise a maltogenic amylase or a beta-amylase and the use of said seeds, optionally in ground form, for catalyzing an industrial process, such as e.g. in baking. The maltogenic amylase providing an anti staling effect in bread produced from the seeds in question.Type: ApplicationFiled: December 15, 2010Publication date: April 14, 2011Applicant: Novozymes A/SInventors: Jack Bech Nielsen, Søren Kjaerulff
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Publication number: 20100188870Abstract: An apparatus and a method for converting power from a power input to an DC output voltage or current, which apparatus has a serial resonance converter, where a first feedback circuit is connected from the output terminal to an error amplifier, where the apparatus further has a second feedback circuit with at least one first resistor that is connected to a coil and to ground, which second feed back circuit connects the line between the first resistor and the coil and towards an inverting integrator, the output of which is connected through a second capacitor to a second input at a control circuit. As a result, the oscillating frequency is under influence of a signal that depends on the voltage generated in the resistor connected in serial to the coil or transformer.Type: ApplicationFiled: February 2, 2010Publication date: July 29, 2010Applicant: BANG & OLUFSEN A/SInventor: Soeren Kjaerulff CHRISTENSEN
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Publication number: 20100016232Abstract: The present invention relates to suppression of TNF-alpha activity with mammal beta defensins, which has utility in the treatment of pathological conditions associated with tumor necrosis factor alpha.Type: ApplicationFiled: July 17, 2009Publication date: January 21, 2010Applicant: Novozymes A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Publication number: 20100016231Abstract: The present invention relates to treatment of rheumatoid arthritis with mammal beta defensins.Type: ApplicationFiled: July 17, 2009Publication date: January 21, 2010Applicant: Novozymes A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Publication number: 20100016230Abstract: The present invention relates to treatment of inflammatory bowel diseases with mammal beta defensins.Type: ApplicationFiled: July 17, 2009Publication date: January 21, 2010Applicant: Novozymes A/SInventors: Tanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Patent number: 7601527Abstract: The invention relates to a variant of a parent Termamyl-like ?-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an ?-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an ?-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an ?-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an ?-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like ?-amylase, which variant exhibits increased.Type: GrantFiled: January 19, 2005Date of Patent: October 13, 2009Assignee: Novozymes A/SInventors: Allan Svendsen, Sóeren Kjaerulff, Henrik Bisgaard-Frantzen, Carsten Andersen
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Patent number: 7455990Abstract: A method is described for releasing a soluble or membrane associated intracellular protein of interest (POI) comprising the steps of: providing a cell comprising a soluble or membrane associated intracellular POI; contacting the cell with a membrane extracting composition; and causing the POI to be released from the cell under conditions sufficient for the specific release of the POI and in a soluble form.Type: GrantFiled: October 24, 2003Date of Patent: November 25, 2008Assignee: Danisco A/SInventors: Claus Lindvald Johansen, Søren Kjaerulff, Susan Mampusta Madrid, Henrik Pedersen, Charlotte Horsmans Poulsen, Masoud Rajabi Zargahi
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Publication number: 20050196853Abstract: The invention relates to a variant of a parent Termamyl-like ?-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an ?-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an ?-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an ?-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an ?-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like ?-amylase, which variant exhibits increased.Type: ApplicationFiled: January 19, 2005Publication date: September 8, 2005Applicant: Novozymes A/SInventors: Allan Svendsen, Soeren Kjaerulff, Henrik Bisgaard-Frantzen, Carsten Andersen