Abstract: An autoinjector (100?) for expelling a single dose of a drug from a held cartridge (600) comprising a piston (630). The autoinjector includes a needle shield (350, 380?) axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380?) is operatively coupled to a plunger release element (320?, 1320) cooperating with a plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320?, 1320) threadedly engaged with a base thread component (204?, 1204) in a predefined relative rotational and axial position and against rotational bias provided by an actuator (330). The needle shield (350, 380?) is configured for operating the retaining mechanism to release the retaining of the plunger release element (320?, 1320) and the base thread component (204?, 1204) from the predefined relative rotational and axial position upon the needle shield (350, 380?) being moved into the trigger release position.

Abstract: A method of manufacturing one of a range of autoinjectors having cartridges (600, 600?, 600?) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c?, 100c?), b) providing a cartridge (600, 600?, 600?) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600?, 600?), d) providing a ram spacer member (400, 400?, 400?), the ram spacer member defining a spacing geometry of length dimension (X1?, X1?, X1??, XS?, XS?, XS??, XR?, XR?, XR??) selected according to the fill volume of the cartridge (600, 600?, 600?), and e) assembling a front body assembly (100b, 100c, 100c?, 100c?), the cartridge (600, 600?, 600?), the ram spacer member (400, 400?, 400?) and the rear body assembly (100a) so that the ram spacer member (400, 400?, 400?) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a)

Abstract: An injection needle assembly (50) for an injection device, having a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises a collapsible wall area (15) having wall thickness t1 less than a predefined wall thickness t1,lim to provide radial deformability for abutting contact with the needle cannula (3).

Abstract: A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position.

Abstract: An autoinjector (100) for expelling a single dose of drug from a drug cartridge (600) including a piston (630), the autoinjector including: a base (200, 220), a needle (500) that is fixedly mounted relative to the base (200, 220), a plunger (310, 320, 400) adapted for cooperation with the piston (630), an actuating spring (330) provided as a helical compression spring arranged to act on the plunger (310, 320, 400) by exerting an axial force on the plunger to drive the piston (630) distally, and a needle shield (350, 380) axially movable relative to the base (200, 220) between an extended position and a collapsed position. The autoinjector defines a lock (320, 328, 380, 388) that is released when the needle shield (350, 380) is moved from the extended position to the collapsed position.

Abstract: An autoinjector (100?) for expelling a single dose of drug from a held cartridge (600) comprising a piston (630). The autoinjector comprises a base (220, 200?) comprising a base thread component (204?) and a plunger (310, 400) configured to be moved by a force provided by an actuator (330) and adapted for cooperation with the piston (630). A needle shield (350, 380?) is axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380?) is operatively coupled to a plunger release element (320?) cooperating with the plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320?) threadedly engaged with the base thread component (204?) in a predefined relative rotational and axial position and against rotational bias provided by the actuator (330).

Abstract: An injection device for expelling a dose of drug from a held cartridge (600) is described. A needle shield (350, 380) is axially movable relative to a base (200, 220, 230) between a proximal collapsed position and a distal extended position. A needle shield lock comprises a deflectable lock element (392) operable to prevent the needle shield (350, 380) from being moved towards the proximal collapsed position. A lock activator (402) associated with a plunger (310, 400) exerts an activation force on the deflectable lock element when the plunger assumes a final position. A biasing means (403) is arranged to act between the lock activator (402) and the deflectable lock element (392), the biasing means (403) being configured to resiliency transfer the activation force from the lock activator (402) to the deflectable lock element (392) to enable the needle shield (350, 380) to become locked in the distal extended position but only when the plunger (310, 400) assumes the final position.

Abstract: An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises a collapsible wall area (15) having wall thickness t1 less than a predefined wall thickness t1,lim to provide radial deformability for abutting contact with the needle cannula (3).

Abstract: A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position.

Abstract: A method of manufacturing one of a range of autoinjectors having cartridges (600, 600?, 600?) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c?, 100c?), b) providing a cartridge (600, 600?, 600?) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600?, 600?), d) providing a ram spacer member (400, 400?, 400?), the ram spacer member defining a spacing geometry of length dimension (X1?, X1?, X1??, XS?, XS?, XS??, XR?, XR?, XR??) selected according to the fill volume of the cartridge (600, 600?, 600?), and e) assembling a front body assembly (100b, 100c, 100c?, 100c?), the cartridge (600, 600?, 600?), the ram spacer member (400, 400?, 400?) and the rear body assembly (100a) so that the ram spacer member (400, 400?, 400?) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a)

Abstract: An autoinjector (100) for expelling a dose of a drug from a held cartridge (600) is described. A needle shield (350, 380) is axially movable relative to a base (200, 220) between an extended position and a collapsed position to operate a trigger lock (328, 388) configured for releasably maintaining a plunger (310, 400) in an initial axial position against the force of an actuator (330). One of the needle shield (350, 380) and the base (200, 220) defines one or more contact surfaces (382) each being resiliently slideable over a respective cooperating ramp surface (212) formed in the other of the needle shield (350, 380) and the base (200, 220) to provide a resistance to movement of the needle shield (350, 380) during needle shield displacement from the extended position towards the collapsed position. A high resistance to movement is obtained in a first stage of said needle shield displacement followed by a low resistance to movement in a second stage.

Abstract: An injection device for expelling a dose of drug from a held cartridge (600) is described. A needle shield (350, 380) is axially movable relative to a base (200, 220, 230) between a proximal collapsed position and a distal extended position. A needle shield lock comprises a deflectable lock element (392) operable to prevent the needle shield (350, 380) from being moved towards the proximal collapsed position. A lock activator (402) associated with a plunger (310, 400) exerts an activation force on the deflectable lock element when the plunger assumes a final position. A biasing means (403) is arranged to act between the lock activator (402) and the deflectable lock element (392), the biasing means (403) being configured to resiliency transfer the activation force from the lock activator (402) to the deflectable lock element (392) to enable the needle shield (350, 380) to become locked in the distal extended position but only when the plunger (310, 400) assumes the final position.

Abstract: An autoinjector (100) for expelling a single dose of drug from a held cartridge (600) comprising a piston (630), the autoinjector comprising: a) a base (200, 220), b) a needle (500) that is fixedly mounted relative to the base (200, 220), c) a plunger (310, 320, 400) adapted for cooperation with the piston (630), d) an actuating spring (330) arranged to act on the plunger (310, 320, 400) to drive the piston (630) distally, and e) a needle shield (350, 380) axially movable relative to the base (200, 220) between an extended position and a collapsed position. In an initial state, a thread (325) of the plunger (310, 320, 400) engages a base thread (205) to maintain the plunger in an initial axial position. The autoinjector defines a lock (320, 328, 380, 388) that is released when the needle shield (350, 380) is moved from the extended position to the collapsed position.

Abstract: A piston rod drive system is provided comprising a main body adapted for coupling with a reservoir, a user operable activation element operatively coupled with the main body and configured to move axially and rotationally relative to the main body between a first position and a second position, and a piston rod element operatively coupled with the activation element and the main body and configured to move axially and non-rotationally relative to the main body in response to the activation element being moved between the first position and the second position.

Abstract: A drug delivery device (1) for mixing substances and administering a final drug product, the device comprising a container having compartments for individual storage of the substances and means for allowing the substances to be mixed. Pistons are arranged in the container and adapted to be moved by a piston driver which is operatively coupled with a user manipulable wheel (106).